PMID- 10381885
OWN - NLM
STAT- MEDLINE
DCOM- 19990715
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5423
DP  - 1999 Jun 25
TI  - Receptor for motilin identified in the human gastrointestinal system.
PG  - 2184-8
AB  - Motilin is a 22-amino acid peptide hormone expressed throughout the
      gastrointestinal (GI) tract of humans and other species. It affects gastric
      motility by stimulating interdigestive antrum and duodenal contractions. A
      heterotrimeric guanosine triphosphate-binding protein (G protein)-coupled
      receptor for motilin was isolated from human stomach, and its amino acid sequence
      was found to be 52 percent identical to the human receptor for growth hormone
      secretagogues. The macrolide antibiotic erythromycin also interacted with the
      cloned motilin receptor, providing a molecular basis for its effects on the human
      GI tract. The motilin receptor is expressed in enteric neurons of the human
      duodenum and colon. Development of motilin receptor agonists and antagonists may 
      be useful in the treatment of multiple disorders of GI motility.
FAU - Feighner, S D
AU  - Feighner SD
AD  - Department of Metabolic Disorders, Department of Medicinal Chemistry, Merck
      Research Laboratories, Building RY-80Y-265, 126 East Lincoln Avenue, Rahway, NJ
      07065, USA.
FAU - Tan, C P
AU  - Tan CP
FAU - McKee, K K
AU  - McKee KK
FAU - Palyha, O C
AU  - Palyha OC
FAU - Hreniuk, D L
AU  - Hreniuk DL
FAU - Pong, S S
AU  - Pong SS
FAU - Austin, C P
AU  - Austin CP
FAU - Figueroa, D
AU  - Figueroa D
FAU - MacNeil, D
AU  - MacNeil D
FAU - Cascieri, M A
AU  - Cascieri MA
FAU - Nargund, R
AU  - Nargund R
FAU - Bakshi, R
AU  - Bakshi R
FAU - Abramovitz, M
AU  - Abramovitz M
FAU - Stocco, R
AU  - Stocco R
FAU - Kargman, S
AU  - Kargman S
FAU - O'Neill, G
AU  - O'Neill G
FAU - Van Der Ploeg, L H
AU  - Van Der Ploeg LH
FAU - Evans, J
AU  - Evans J
FAU - Patchett, A A
AU  - Patchett AA
FAU - Smith, R G
AU  - Smith RG
FAU - Howard, A D
AU  - Howard AD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Ligands)
RN  - 0 (Receptors, Gastrointestinal Hormone)
RN  - 0 (Receptors, Neuropeptide)
RN  - 0 (motilin receptor)
RN  - 52906-92-0 (Motilin)
RN  - 63937KV33D (Erythromycin)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Binding Sites
MH  - Calcium/metabolism
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 13
MH  - Cloning, Molecular
MH  - Colon/*metabolism
MH  - Erythromycin/metabolism
MH  - GTP-Binding Proteins/metabolism
MH  - Gastric Mucosa/*metabolism
MH  - Humans
MH  - In Situ Hybridization
MH  - Intestine, Small/*metabolism
MH  - Ligands
MH  - Molecular Sequence Data
MH  - Motilin/analogs & derivatives/*metabolism
MH  - Receptors, Gastrointestinal Hormone/*chemistry/*genetics/metabolism
MH  - Receptors, Neuropeptide/*chemistry/*genetics/metabolism
MH  - Thyroid Gland/metabolism
MH  - Transfection
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
AID - 7615 [pii]
AID - 10.1126/science.284.5423.2184 [doi]
PST - ppublish
SO  - Science. 1999 Jun 25;284(5423):2184-8. doi: 10.1126/science.284.5423.2184.