PMID- 10381882
OWN - NLM
STAT- MEDLINE
DCOM- 19990715
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5423
DP  - 1999 Jun 25
TI  - Regulation of transcription by a protein methyltransferase.
PG  - 2174-7
AB  - The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate
      transcriptional activation by nuclear hormone receptors. Coactivator-associated
      arginine methyltransferase 1 (CARM1), a previously unidentified protein that
      binds to the carboxyl-terminal region of p160 coactivators, enhanced
      transcriptional activation by nuclear receptors, but only when GRIP1 or SRC-1a
      was coexpressed. Thus, CARM1 functions as a secondary coactivator through its
      association with p160 coactivators. CARM1 can methylate histone H3 in vitro, and 
      a mutation in the putative S-adenosylmethionine binding domain of CARM1
      substantially reduced both methyltransferase and coactivator activities. Thus,
      coactivator-mediated methylation of proteins in the transcription machinery may
      contribute to transcriptional regulation.
FAU - Chen, D
AU  - Chen D
AD  - Department of Pathology HMR 301, University of Southern California, 2011 Zonal
      Avenue, Los Angeles, CA 90033, USA.
FAU - Ma, H
AU  - Ma H
FAU - Hong, H
AU  - Hong H
FAU - Koh, S S
AU  - Koh SS
FAU - Huang, S M
AU  - Huang SM
FAU - Schurter, B T
AU  - Schurter BT
FAU - Aswad, D W
AU  - Aswad DW
FAU - Stallcup, M R
AU  - Stallcup MR
LA  - eng
SI  - GENBANK/AF117887
GR  - AG00093/AG/NIA NIH HHS/United States
GR  - DK43093/DK/NIDDK NIH HHS/United States
GR  - NS17269/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Histones)
RN  - 0 (Ncoa2 protein, mouse)
RN  - 0 (Nuclear Receptor Coactivator 2)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 2.1.1.319 (Protein-Arginine N-Methyltransferases)
RN  - EC 2.1.1.319 (coactivator-associated arginine methyltransferase 1)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (Ncoa1 protein, mouse)
RN  - EC 2.3.1.48 (Ncoa3 protein, mouse)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 3)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Histone Acetyltransferases
MH  - Histones/metabolism
MH  - Methylation
MH  - Mice
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Nuclear Receptor Coactivator 1
MH  - Nuclear Receptor Coactivator 2
MH  - Nuclear Receptor Coactivator 3
MH  - Protein-Arginine N-Methyltransferases/chemistry/genetics/*metabolism
MH  - Receptors, Androgen/metabolism
MH  - Receptors, Estrogen/metabolism
MH  - Receptors, Thyroid Hormone/metabolism
MH  - Recombinant Fusion Proteins/metabolism
MH  - Signal Transduction
MH  - Trans-Activators/*metabolism
MH  - Transcription Factors/metabolism
MH  - *Transcriptional Activation
MH  - Transfection
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
AID - 7607 [pii]
AID - 10.1126/science.284.5423.2174 [doi]
PST - ppublish
SO  - Science. 1999 Jun 25;284(5423):2174-7. doi: 10.1126/science.284.5423.2174.