PMID- 10381580
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 83
IP  - 1-2
DP  - 1999 May
TI  - Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic
      development.
PG  - 187-90
AB  - Germ-line mutations of LKB1 and PTEN tumor suppressor genes underlie the
      phenotypically related Peutz-Jeghers syndrome (PJS) and Cowden disease (CD),
      respectively. To analyze possible developmental roles of PTEN and LKB1, we have
      studied their mRNA expression during mouse embryonic development (E7-17.5) by in 
      situ hybridization. Ubiquitous expression of both genes during early stages
      (E7-11) became more restricted in later embryonic development (E15-19) where LKB1
      and PTEN showed prominent overlapping expression in e.g. gastrointestinal tract
      and lung. In contrast, LKB1 was selectively expressed at high levels in testis
      and PTEN was prominently expressed in skin epithelium and underlying mesenchyme. 
      These results indicate that LKB1 and PTEN display largely overlapping expression 
      patterns during embryonic development. Moreover, a high expression of these genes
      was observed in the tissues and organs affected in PJS and CD patients and in
      PTEN+/- mice.
CI  - Copyright 1998 Elsevier Science S.A. All rights reserved
FAU - Luukko, K
AU  - Luukko K
AD  - Haartman Institute and Biocentrum Helsinki, P.O. Box 21, 00014 University of
      Helsinki, Helsinki, Finland.
FAU - Ylikorkala, A
AU  - Ylikorkala A
FAU - Tiainen, M
AU  - Tiainen M
FAU - Makela, T P
AU  - Makela TP
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.1.- (Stk11 protein, mouse)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
SB  - IM
MH  - Animals
MH  - Embryo, Mammalian/anatomy & histology
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Tumor Suppressor
MH  - Mice
MH  - PTEN Phosphohydrolase
MH  - Phosphoric Monoester Hydrolases/genetics/*metabolism
MH  - Protein-Serine-Threonine Kinases/genetics/*metabolism
MH  - RNA, Messenger/analysis
MH  - Tissue Distribution
MH  - *Tumor Suppressor Proteins
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - S0925477399000507 [pii]
AID - 10.1016/s0925-4773(99)00050-7 [doi]
PST - ppublish
SO  - Mech Dev. 1999 May;83(1-2):187-90. doi: 10.1016/s0925-4773(99)00050-7.