PMID- 10381577
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 83
IP  - 1-2
DP  - 1999 May
TI  - Genomic structure, mapping, activity and expression of fibroblast growth factor
      17.
PG  - 165-78
AB  - Fibroblast growth factors are essential molecules for development. Here we
      characterize Fgfl7, a new member of the fibroblast growth factor (FGF) family.
      The Fgfl7 gene maps to mouse chromosome 14 and is highly conserved between mouse 
      and human (93% identity). It exhibits 60% amino acid identity with Fgf8 and 50%
      identity with Fgf8. Both Fgf8 and Fgf17 have a similar structure and a similar
      pattern of alternative splicing in the 5' coding region. When expressed in 3T3
      fibroblasts, mouse FGF17 is transforming, indicating that it can activate the 'c'
      splice form of either FGF receptor (FGFR) one or two. During midgestation
      embryogenesis, in situ hybridization analysis localized Fgf17 expression to
      specific sites in the midline structures of the forebrain, the midbrain-hindbrain
      junction, the developing skeleton and in developing arteries. Comparison to Fgf8 
      revealed a striking similarity in expression patterns, especially in the central 
      nervous system (CNS), suggesting that both genes may be important for CNS
      development, although Fgf17 is expressed somewhat later than Fgf8. In the
      developing skeleton, both genes are expressed in costal cartilage while Fgf8 is
      preferentially expressed in long bones. In the developing great vessels Fgfl7 is 
      preferentially expressed, suggesting that it may have a more prominent role in
      vascular growth.
CI  - Copyright 1998 Elsevier Science S.A. All rights reserved
FAU - Xu, J
AU  - Xu J
AD  - Department of Molecular Biology and Pharmacology, Washington University School of
      Medicine, St. Louis, MO 63110, USA.
FAU - Lawshe, A
AU  - Lawshe A
FAU - MacArthur, C A
AU  - MacArthur CA
FAU - Ornitz, D M
AU  - Ornitz DM
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (FGF17 protein, human)
RN  - 0 (FGF8 protein, human)
RN  - 0 (Fgf17 protein, mouse)
RN  - 0 (Fgf8 protein, mouse)
RN  - 148997-75-5 (Fibroblast Growth Factor 8)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
SB  - S
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bone and Bones/embryology
MH  - Brain/embryology
MH  - Chromosome Mapping
MH  - Fibroblast Growth Factor 8
MH  - Fibroblast Growth Factors/analysis/*genetics/*metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Mice
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - S0925477399000349 [pii]
AID - 10.1016/s0925-4773(99)00034-9 [doi]
PST - ppublish
SO  - Mech Dev. 1999 May;83(1-2):165-78. doi: 10.1016/s0925-4773(99)00034-9.