PMID- 10381575
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 83
IP  - 1-2
DP  - 1999 May
TI  - Six9 (Optx2), a new member of the six gene family of transcription factors, is
      expressed at early stages of vertebrate ocular and pituitary development.
PG  - 155-9
AB  - The Drosophila gene sine oculis (so) is a nuclear homeoprotein, which is required
      for eye development. Several homologues of so have been found in vertebrates. We 
      report here a detailed expression analysis in chick and mouse of Six9 (Optx2), a 
      novel gene of the Six/sine oculis family closely related to Six3. Six9 (Optx2) is
      first expressed at presomitic stages in the head-fold, both in the neural plate
      and in the underlying axial mesoderm. Thereafter, Six9 (Optx2) is strongly
      expressed in the presumptive and differentiating neural retina and ventral optic 
      stalk, in the olfactory placodes, in the hypothalamus and in the pituitary gland.
      This expression pattern largely overlaps with that of Six3, but several
      differences exist between the expression domain of the two genes. At presomitic
      stages, the posterior boundary of Six3 expression is at the same axial level both
      in the prechordal plate and in the overlying neural plate. In contrast, Six9
      (Optx2) expression in the prechordal plate extends more caudal to that of the
      neural plate, occupying a more restricted V-shaped territory. Similarly, during
      the early events of eye patterning, Six3 is first expressed in the entire optic
      vesicle and lens placode. Only later does its expression become confined to the
      prospective and differentiating neural retina. Conversely, Six9 (Optx2) is never 
      observed in the lens placode of either chick and mouse, and from early stages of 
      optic vesicle development, Six9 (Optx2) transcripts are restrained to the
      prospective ventral neural retina and optic stalks.
FAU - Lopez-Rios, J
AU  - Lopez-Rios J
AD  - Departamento de Neurobiologia del Desarrollo, Instituto Cajal, Consejo Superior
      de Investigaciones Cientificas, Dr. Arce 37, E28002, Madrid, Spain.
FAU - Gallardo, M E
AU  - Gallardo ME
FAU - Rodriguez de Cordoba, S
AU  - Rodriguez de Cordoba S
FAU - Bovolenta, P
AU  - Bovolenta P
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Six6 protein, mouse)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Animals
MH  - Chick Embryo
MH  - Cloning, Molecular
MH  - Embryo, Mammalian/anatomy & histology
MH  - Embryo, Nonmammalian/anatomy & histology
MH  - Eye/*embryology
MH  - Gene Expression Regulation, Developmental
MH  - Homeodomain Proteins/analysis/*genetics
MH  - Mice
MH  - Morphogenesis
MH  - Pituitary Gland/*embryology
MH  - Trans-Activators/analysis/*genetics
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - S0925477399000179 [pii]
AID - 10.1016/s0925-4773(99)00017-9 [doi]
PST - ppublish
SO  - Mech Dev. 1999 May;83(1-2):155-9. doi: 10.1016/s0925-4773(99)00017-9.