PMID- 10381568
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 83
IP  - 1-2
DP  - 1999 May
TI  - Divergent properties of mouse netrins.
PG  - 65-75
AB  - The netrins are a small but highly conserved family of axonal guidance signals
      found throughout the animal kingdom. This sequence conservation was used to
      isolated cDNAs for two mouse netrins. Analysis of their expression patterns and
      functional properties showed that mouse netrin-1 is in most respects similar to
      its orthologs in other vertebrates while the properties of netrin-3 differ
      markedly from those of other members of this protein family. In contrast to
      netrin-1 which is widely expressed both in the developing nervous system and in
      mesodermal tissues, netrin-3 transcripts are largely restricted to dorsal root
      ganglia and the developing limb buds. Netrin-3 binds with a significantly lower
      affinity to the netrin receptor DCC (deleted in colorectal cancer) and is also
      ineffective in eliciting the outgrowth of commissural axons in vitro. These
      results demonstrate that, although the netrins are highly conserved signals that 
      guide axons to or away from the midline of the developing nervous system, at the 
      same time they show a surprising degree of divergence in vertebrates.
CI  - Copyright 1998 Elsevier Science S.A. All rights reserved
FAU - PuschelPuschel, A W
AU  - PuschelPuschel AW
AD  - Molekulare Neurogenetik, Abteilung Neurochemie, Max-Planck-Institut fur
      Hirnforschung, Deutschordenstraza 46, D-60528 Frankfurt/, Main, Germany.
LA  - eng
SI  - GENBANK/AF128865
SI  - GENBANK/AF128866
PT  - Journal Article
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Netrins)
RN  - 0 (Ntn1 protein, mouse)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (netrin-3)
RN  - 158651-98-0 (Netrin-1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Western
MH  - Brain/embryology
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Embryo, Mammalian/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Nerve Growth Factors/analysis/*metabolism
MH  - Nerve Tissue Proteins/analysis/*metabolism
MH  - Netrin-1
MH  - Netrins
MH  - Phylogeny
MH  - Sequence Homology, Amino Acid
MH  - Tumor Suppressor Proteins
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - S0925477399000350 [pii]
AID - 10.1016/s0925-4773(99)00035-0 [doi]
PST - ppublish
SO  - Mech Dev. 1999 May;83(1-2):65-75. doi: 10.1016/s0925-4773(99)00035-0.