PMID- 10381553
OWN - NLM
STAT- MEDLINE
DCOM- 19990921
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 70
IP  - 1
DP  - 1999 Jun 18
TI  - Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and
      delta-CaM kinase II are the early isoforms and most abundant in the developing
      nervous system.
PG  - 147-54
AB  - CaM kinase II constitutes a family of multifunctional protein kinases that play a
      major role in Ca2+-mediated signal transduction. As a first step in understanding
      their possible function in mouse development we characterized the expression
      patterns of all CaM kinase II isoforms (alpha, beta, gamma and delta) starting in
      prenatal development. Remarkably, only the ubiquitous gamma- and delta-CaM kinase
      II are expressed during early development. Their distribution suggests a special 
      role in the developing nervous system and in mature excitable tissues.
      Additionally, we describe the murine betaM-CaM kinase II, a variant of the
      'brain-specific' beta-CaM kinase II, which is highly expressed in skeletal
      muscle.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Bayer, K U
AU  - Bayer KU
AD  - Department of Neurobiology, Stanford University School of Medicine, 299 Campus
      Drive, Stanford, CA 94305-5125, USA. ulli.bayer@stanford.edu
FAU - Lohler, J
AU  - Lohler J
FAU - Schulman, H
AU  - Schulman H
FAU - Harbers, K
AU  - Harbers K
LA  - eng
SI  - GENBANK/AF108718
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Protein Isoforms)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/embryology/enzymology/growth & development
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*biosynthesis/genetics
MH  - Enzyme Induction
MH  - Ganglia/embryology/enzymology/growth & development
MH  - *Gene Expression Regulation, Developmental
MH  - Head/embryology/growth & development
MH  - Liver/embryology/enzymology/growth & development
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*biosynthesis/genetics
MH  - Nervous System/embryology/*enzymology/growth & development
MH  - Organ Specificity
MH  - Protein Isoforms/*biosynthesis/genetics
MH  - Spinal Cord/embryology/enzymology/growth & development
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - S0169328X9900131X [pii]
AID - 10.1016/s0169-328x(99)00131-x [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1999 Jun 18;70(1):147-54. doi:
      10.1016/s0169-328x(99)00131-x.