PMID- 10381005
OWN - NLM
STAT- MEDLINE
DCOM- 19990803
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 267
IP  - 3
DP  - 1999 Jun 4
TI  - Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and
      tyrosine hydroxylase.
PG  - 177-80
AB  - Cyclic AMP transiently stimulates transcription of specific genes in the nervous 
      system, including neural-specific gene VGF. The simultaneous presence of
      staurosporine (SSP) caused a progressive, rather than transient, increase in VGF 
      mRNA levels during the cAMP-induced differentiation of human neuroblastoma cells.
      This steady increase does not appear to be due to increased stability of VGF
      mRNA. This synergy between cAMP and SSP was also observed at the protein level
      for tyrosine hydroxylase. These findings suggest the presence of cellular
      machinery that counteracts the decline of cAMP-induced gene expression.
FAU - Nagasaki, K
AU  - Nagasaki K
AD  - Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan. 
      knagasak@gan2.ncc.go.jp
FAU - Sasaki, K
AU  - Sasaki K
FAU - Maass, N
AU  - Maass N
FAU - Tsukada, T
AU  - Tsukada T
FAU - Hanzawa, H
AU  - Hanzawa H
FAU - Yamaguchi, K
AU  - Yamaguchi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Neuropeptides)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vgf protein, rat)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - H88EPA0A3N (Staurosporine)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/drug effects
MH  - Cyclic AMP/*physiology
MH  - Enzyme Inhibitors/*pharmacology
MH  - Humans
MH  - Neurites/drug effects/metabolism
MH  - Neuropeptides
MH  - Proteins/*drug effects/genetics
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Staurosporine/*pharmacology
MH  - Tumor Cells, Cultured
MH  - Tyrosine 3-Monooxygenase/*drug effects/genetics/metabolism
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - S0304394099003596 [pii]
AID - 10.1016/s0304-3940(99)00359-6 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Jun 4;267(3):177-80. doi: 10.1016/s0304-3940(99)00359-6.