PMID- 10380924
OWN - NLM
STAT- MEDLINE
DCOM- 19990722
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 97
IP  - 6
DP  - 1999 Jun 11
TI  - WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity
      signals in C. elegans.
PG  - 717-26
AB  - During C. elegans development, Wnt/WG signaling is required for differences in
      cell fate between sister cells born from anterior/posterior divisions. A
      beta-catenin-related gene, wrm-1, and the lit-1 gene are effectors of this
      signaling pathway and appear to downregulate the activity of POP-1, a
      TCF/LEF-related protein, in posterior daughter cells. We show here that lit-1
      encodes a serine/threonine protein kinase homolog related to the Drosophila
      tissue polarity protein Nemo. We demonstrate that the WRM-1 protein binds to
      LIT-1 in vivo and that WRM-1 can activate the LIT-1 protein kinase when
      coexpressed in vertebrate tissue culture cells. This activation leads to
      phosphorylation of POP-1 and to apparent changes in its subcellular localization.
      Our findings provide evidence for novel regulatory avenues for an evolutionarily 
      conserved Wnt/WG signaling pathway.
FAU - Rocheleau, C E
AU  - Rocheleau CE
AD  - University of Massachusetts Medical School, Program in Molecular Medicine,
      Worcester 01605, USA.
FAU - Yasuda, J
AU  - Yasuda J
FAU - Shin, T H
AU  - Shin TH
FAU - Lin, R
AU  - Lin R
FAU - Sawa, H
AU  - Sawa H
FAU - Okano, H
AU  - Okano H
FAU - Priess, J R
AU  - Priess JR
FAU - Davis, R J
AU  - Davis RJ
FAU - Mello, C C
AU  - Mello CC
LA  - eng
SI  - GENBANK/AF143243
SI  - GENBANK/AF143244
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Helminth Proteins)
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mom-5 protein, C elegans)
RN  - 0 (Trans-Activators)
RN  - 0 (WRM-1 protein, C elegans)
RN  - 0 (beta Catenin)
RN  - 0 (pop-1 protein, C elegans)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (lit-1 protein, C elegans)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - COS Cells
MH  - Caenorhabditis elegans/genetics/metabolism
MH  - *Caenorhabditis elegans Proteins
MH  - Cytoskeletal Proteins/genetics/*metabolism
MH  - DNA-Binding Proteins/metabolism
MH  - Enzyme Activation
MH  - Helminth Proteins/genetics/*metabolism
MH  - High Mobility Group Proteins/metabolism
MH  - Membrane Proteins/genetics/*metabolism
MH  - *Mitogen-Activated Protein Kinases
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Protein-Serine-Threonine Kinases/genetics/metabolism
MH  - *Signal Transduction
MH  - *Trans-Activators
MH  - beta Catenin
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - S0092-8674(00)80784-9 [pii]
AID - 10.1016/s0092-8674(00)80784-9 [doi]
PST - ppublish
SO  - Cell. 1999 Jun 11;97(6):717-26. doi: 10.1016/s0092-8674(00)80784-9.