PMID- 10377453
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 13
DP  - 1999 Jun 22
TI  - Selective loss of cone function in mice lacking the cyclic nucleotide-gated
      channel CNG3.
PG  - 7553-7
AB  - Two types of photoreceptors, rods and cones, coexist in the vertebrate retina. An
      in-depth analysis of the retinal circuitry that transmits rod and cone signals
      has been hampered by the presence of intimate physical and functional connections
      between rod and cone pathways. By deleting the cyclic nucleotide-gated channel
      CNG3 we have generated a mouse lacking any cone-mediated photoresponse. In
      contrast, the rod pathway is completely intact in CNG3-deficient mice. The
      functional loss of cone function correlates with a progressive degeneration of
      cone photoreceptors but not of other retinal cell types. CNG3-deficient mice
      provide an animal model to dissect unequivocally the contribution of rod and cone
      pathways for normal retinal function.
FAU - Biel, M
AU  - Biel M
AD  - Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen,
      Biedersteiner Strasse 29, 80802 Munich, Germany.
FAU - Seeliger, M
AU  - Seeliger M
FAU - Pfeifer, A
AU  - Pfeifer A
FAU - Kohler, K
AU  - Kohler K
FAU - Gerstner, A
AU  - Gerstner A
FAU - Ludwig, A
AU  - Ludwig A
FAU - Jaissle, G
AU  - Jaissle G
FAU - Fauser, S
AU  - Fauser S
FAU - Zrenner, E
AU  - Zrenner E
FAU - Hofmann, F
AU  - Hofmann F
LA  - eng
SI  - GENBANK/AJ238239
SI  - GENBANK/AJ238240
SI  - GENBANK/AJ238241
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Cyclic Nucleotide-Gated Cation Channels)
RN  - 0 (Eye Proteins)
RN  - 0 (Ion Channels)
SB  - IM
MH  - Animals
MH  - Cyclic Nucleotide-Gated Cation Channels
MH  - Electrophysiology
MH  - Eye Proteins/genetics
MH  - Gene Deletion
MH  - Gene Expression Regulation/*physiology
MH  - Ion Channels/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Retinal Cone Photoreceptor Cells/*physiology
PMC - PMC22124
EDAT- 1999/06/23 00:00
MHDA- 1999/06/23 00:01
CRDT- 1999/06/23 00:00
PHST- 1999/06/23 00:00 [pubmed]
PHST- 1999/06/23 00:01 [medline]
PHST- 1999/06/23 00:00 [entrez]
AID - 10.1073/pnas.96.13.7553 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7553-7. doi:
      10.1073/pnas.96.13.7553.