PMID- 10377394
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 13
DP  - 1999 Jun 22
TI  - NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and
      Jun.
PG  - 7214-9
AB  - NFAT transcription factors are related to NF-kappaB/Rel proteins and form
      cooperative complexes with Fos and Jun on DNA. We have identified an NFAT-related
      protein, NFAT5, which differs from the conventional NFAT proteins NFAT1-4 in its 
      structure, DNA binding, and regulation. NFAT5 contains a NFAT-like Rel homology
      domain, conserves the DNA contact residues of NFAT1-4, and binds DNA sequences
      similar to those found in the regulatory regions of well-characterized
      NFAT-dependent genes. However, it lacks the majority of Fos/Jun contact residues 
      and does not bind cooperatively with Fos and Jun to DNA. Unlike NFAT1-4, whose
      nuclear import is tightly regulated by calcineurin-mediated dephosphorylation,
      NFAT5 is a constitutively nuclear phosphoprotein regardless of calcineurin
      activation. These features suggest that unlike the conventional NFAT proteins,
      NFAT1-4, which activate gene transcription by integrating inputs from
      calcium/calcineurin and protein kinase C/mitogen-activated protein kinase
      signaling pathways, NFAT5 participates in as-yet-unidentified signaling pathways 
      in diverse immune and nonimmune cells.
FAU - Lopez-Rodriguez, C
AU  - Lopez-Rodriguez C
AD  - Department of Pathology, Harvard Medical School, The Center for Blood Research,
      Boston, MA 02115, USA.
FAU - Aramburu, J
AU  - Aramburu J
FAU - Rakeman, A S
AU  - Rakeman AS
FAU - Rao, A
AU  - Rao A
LA  - eng
SI  - GENBANK/AF134870
GR  - R01 AI040127/AI/NIAID NIH HHS/United States
GR  - CA-42471/CA/NCI NIH HHS/United States
GR  - R01 CA042471/CA/NCI NIH HHS/United States
GR  - R37 CA042471/CA/NCI NIH HHS/United States
GR  - AI-40127/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line, Transformed
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Gene Expression Regulation
MH  - *Genes, fos
MH  - *Genes, jun
MH  - Mice
MH  - Molecular Sequence Data
MH  - NF-kappa B/genetics
MH  - NFATC Transcription Factors
MH  - Nuclear Proteins/*genetics/metabolism
MH  - Sequence Alignment
MH  - Transcription Factors/*genetics/metabolism
PMC - PMC22056
EDAT- 1999/06/23 00:00
MHDA- 1999/06/23 00:01
CRDT- 1999/06/23 00:00
PHST- 1999/06/23 00:00 [pubmed]
PHST- 1999/06/23 00:01 [medline]
PHST- 1999/06/23 00:00 [entrez]
AID - 10.1073/pnas.96.13.7214 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7214-9. doi:
      10.1073/pnas.96.13.7214.