PMID- 10377282 OWN - NLM STAT- MEDLINE DCOM- 20000316 LR - 20190921 IS - 0959-437X (Print) IS - 0959-437X (Linking) VI - 9 IP - 3 DP - 1999 Jun TI - The roles of RNA-binding proteins in spermatogenesis and male infertility. PG - 346-54 AB - RNA-binding proteins are essential for spermatogenesis: they are required in the nucleus of germ cells, for the production of specific mRNA isoforms, and in the cytoplasm - where proteins required for chromatin condensation and for changes in cell morphology are translated long after transcription ceases. Some of the RNA targets and the RNA-binding proteins themselves have been identified recently. Both nuclear and cytoplasmic proteins are affected in examples of azoospermia in men. FAU - Venables, J P AU - Venables JP AD - Department of Biochemistry University of Leicester University Road, Leicester, LE1 7RH, UK. J.Venables@hgu.mrc.ac.uk FAU - Eperon, I AU - Eperon I LA - eng PT - Journal Article PT - Review PL - England TA - Curr Opin Genet Dev JT - Current opinion in genetics & development JID - 9111375 RN - 0 (Nuclear Proteins) RN - 0 (RNA-Binding Proteins) SB - IM MH - Animals MH - Cytoplasm/metabolism MH - Humans MH - Infertility, Male/*physiopathology MH - Male MH - Nuclear Proteins/physiology MH - RNA-Binding Proteins/*physiology MH - Spermatogenesis/*physiology RF - 84 EDAT- 1999/06/23 10:00 MHDA- 2000/05/29 09:00 CRDT- 1999/06/23 10:00 PHST- 1999/06/23 10:00 [pubmed] PHST- 2000/05/29 09:00 [medline] PHST- 1999/06/23 10:00 [entrez] AID - gd9305 [pii] AID - 10.1016/s0959-437x(99)80052-5 [doi] PST - ppublish SO - Curr Opin Genet Dev. 1999 Jun;9(3):346-54. doi: 10.1016/s0959-437x(99)80052-5.