PMID- 10376527
OWN - NLM
STAT- MEDLINE
DCOM- 19990630
LR  - 20091119
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 23
DP  - 1999 Jun 10
TI  - Role of the ATFa/JNK2 complex in Jun activation.
PG  - 3491-500
AB  - The ATFa proteins, which are members of the CREB/ATF family of transcription
      factors, display quite versatile properties. We have previously shown that they
      interact with the adenovirus E1a oncoprotein, mediating part of its
      transcriptional activity and heterodimerize with the Jun, Fos or related
      transcription factors, thereby modulating their DNA-binding specificity. In the
      present study, we report the sequence requirement of the N-terminal activation
      domain of ATFa and demonstrate the importance of specific threonine residues
      (Thr51 and Thr53) in addition to that of the metal-binding domain, in
      transcriptional activation processes. We also show that the N-terminal domain of 
      ATFa which stably binds the Jun N-terminal kinase-2 (JNK2) (Bocco et al., 1996), 
      is not a substrate for this kinase in vivo but, instead, serves as a JNK2-docking
      site for ATFa-associated partners like JunD, allowing them to be phosphorylated
      by the bound kinase.
FAU - De Graeve, F
AU  - De Graeve F
AD  - Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM/CNRS/ULP, 
      Illkirch, CU de Strasbourg, France.
FAU - Bahr, A
AU  - Bahr A
FAU - Sabapathy, K T
AU  - Sabapathy KT
FAU - Hauss, C
AU  - Hauss C
FAU - Wagner, E F
AU  - Wagner EF
FAU - Kedinger, C
AU  - Kedinger C
FAU - Chatton, B
AU  - Chatton B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Activating Transcription Factor 1)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.24 (Mitogen-Activated Protein Kinase 9)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Activating Transcription Factor 1
MH  - Animals
MH  - COS Cells
MH  - Cell Line
MH  - *DNA-Binding Proteins
MH  - Mitogen-Activated Protein Kinase 9
MH  - *Mitogen-Activated Protein Kinases
MH  - Peptide Fragments/*physiology
MH  - Phosphorylation
MH  - Protein Kinases/*physiology
MH  - Proto-Oncogene Proteins c-jun/metabolism
MH  - Transcription Factors/*physiology
MH  - Transcriptional Activation/*physiology
EDAT- 1999/06/22 00:00
MHDA- 1999/06/22 00:01
CRDT- 1999/06/22 00:00
PHST- 1999/06/22 00:00 [pubmed]
PHST- 1999/06/22 00:01 [medline]
PHST- 1999/06/22 00:00 [entrez]
AID - 10.1038/sj.onc.1202723 [doi]
PST - ppublish
SO  - Oncogene. 1999 Jun 10;18(23):3491-500. doi: 10.1038/sj.onc.1202723.