PMID- 10373014
OWN - NLM
STAT- MEDLINE
DCOM- 19990806
LR  - 20141120
IS  - 1058-8388 (Print)
IS  - 1058-8388 (Linking)
VI  - 215
IP  - 2
DP  - 1999 Jun
TI  - RARbeta mediates the response of Hoxd4 and Hoxb4 to exogenous retinoic acid.
PG  - 96-107
AB  - One action of retinoids in development is the regulation of Hox gene expression. 
      Hoxd4 and Hoxb4 expression in the embryonic hindbrain is anteriorized by retinoic
      acid (RA) treatment of mid-gestation mouse embryos. Here we demonstrate that
      retinoic acid receptor beta (Rarb) deficient mice present only a partial
      anteriorization of either Hoxd4 or Hoxb4 in response to RA treatment. Our results
      strongly suggest that RARbeta is a mediator of their RA-response, and reveal
      anteroposterior polarity within a single rhombomere (r). Additionally, we
      generated mice doubly mutated for Hoxd4 and Rarb in an attempt to identify common
      morphogenetic pathways between these two genes. We conclude that there are no
      synergistic interactions between Hoxd4 and Rarb in the specification of the
      cervical vertebrae.
FAU - Folberg, A
AU  - Folberg A
AD  - McGill Cancer Centre, Department of Medicine, McGill University, Montreal,
      Quebec, Canada.
FAU - Nagy Kovacs, E
AU  - Nagy Kovacs E
FAU - Luo, J
AU  - Luo J
FAU - Giguere, V
AU  - Giguere V
FAU - Featherstone, M S
AU  - Featherstone MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of
      Anatomists
JID - 9201927
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Hoxb4 protein, mouse)
RN  - 0 (Hoxd3 protein, mouse)
RN  - 0 (Hoxd4 protein, mouse)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Transcription Factors)
RN  - 0 (retinoic acid receptor beta)
RN  - 127609-92-1 (HOXA4 protein, human)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - *DNA-Binding Proteins
MH  - Embryonic and Fetal Development
MH  - Gene Expression Regulation, Developmental
MH  - Homeodomain Proteins/*genetics
MH  - Mice
MH  - Mice, Knockout
MH  - Mutagenesis
MH  - Receptors, Retinoic Acid/genetics/*physiology
MH  - Transcription Factors/*genetics
MH  - Tretinoin/*metabolism/pharmacology
EDAT- 1999/06/18 10:00
MHDA- 2000/06/22 10:00
CRDT- 1999/06/18 10:00
PHST- 1999/06/18 10:00 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1999/06/18 10:00 [entrez]
AID - 10.1002/(SICI)1097-0177(199906)215:2<96::AID-DVDY2>3.0.CO;2-T [pii]
AID - 10.1002/(SICI)1097-0177(199906)215:2<96::AID-DVDY2>3.0.CO;2-T [doi]
PST - ppublish
SO  - Dev Dyn. 1999 Jun;215(2):96-107. doi:
      10.1002/(SICI)1097-0177(199906)215:2<96::AID-DVDY2>3.0.CO;2-T.