PMID- 10371200
OWN - NLM
STAT- MEDLINE
DCOM- 19990701
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 451
IP  - 3
DP  - 1999 May 28
TI  - Evolutionary divergence in the broad complex, tramtrack and bric a
      brac/poxviruses and zinc finger domain from the candidate tumor suppressor gene
      hypermethylated in cancer.
PG  - 253-6
AB  - Hypermethylated in cancer, a new candidate tumor suppressor gene located in
      17p13.3, encodes a protein with five Kruppel-like C2H2 zinc finger motifs and a
      N-terminal protein/protein interaction domain called broad complex, tramtrack and
      bric a brac/poxviruses and zinc finger domain. Hypermethylated in cancer appears 
      unique in the broad complex, tramtrack and bric a brac/poxviruses and zinc finger
      family since it contains a 13 amino acid insertion located in a loop between the 
      conserved beta-strand beta5 and helix alpha5 which are involved in dimerization
      and scaffolding of the broad complex, tramtrack and bric a brac/poxviruses and
      zinc finger domain. Cloning and sequencing of a murine hypermethylated in cancer 
      gene suggests that this insertion has been acquired late in the evolution since
      it is present in two mammalian hypermethylated in cancer genes but absent in its 
      zebrafish and avian counterparts. This is a unique example of a high divergence
      of the same broad complex, tramtrack and bric a brac/poxviruses and zinc finger
      domain in different species.
FAU - Guerardel, C
AU  - Guerardel C
AD  - CNRS UMR 8526, Institut de Biologie de Lille, Institut Pasteur de Lille, France.
FAU - Deltour, S
AU  - Deltour S
FAU - Leprince, D
AU  - Leprince D
LA  - eng
SI  - GENBANK/AJ132691
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Br protein, Drosophila)
RN  - 0 (Bric-a-brac protein 1, Drosophila)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Hic1 protein, mouse)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (ttk protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - DNA Methylation
MH  - DNA-Binding Proteins/*genetics
MH  - *Drosophila Proteins
MH  - Evolution, Molecular
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/*genetics
MH  - Repressor Proteins/*genetics
MH  - Sequence Alignment
MH  - Sequence Analysis
MH  - Transcription Factors/*genetics
MH  - Zinc Fingers/genetics
EDAT- 1999/06/17 00:00
MHDA- 1999/06/17 00:01
CRDT- 1999/06/17 00:00
PHST- 1999/06/17 00:00 [pubmed]
PHST- 1999/06/17 00:01 [medline]
PHST- 1999/06/17 00:00 [entrez]
AID - S0014-5793(99)00583-9 [pii]
AID - 10.1016/s0014-5793(99)00583-9 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 May 28;451(3):253-6. doi: 10.1016/s0014-5793(99)00583-9.