PMID- 10370142
OWN - NLM
STAT- MEDLINE
DCOM- 19990706
LR  - 20190720
IS  - 0302-766X (Print)
IS  - 0302-766X (Linking)
VI  - 296
IP  - 3
DP  - 1999 Jun
TI  - Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the
      human breast.
PG  - 549-54
AB  - In the mouse mammary gland, homeobox gene expression patterns suggest roles in
      development and neoplasia. In the human breast, we now identify a family of
      Iroquois-class (IRX) homeobox genes. One gene, IRX-2, is expressed in discrete
      epithelial cell lineages being found in ductal and lobular epithelium, but not in
      myoepithelium. Expression is absent from associated mesenchymal adipose stroma.
      During gland development, expression is concentrated in terminal end buds and
      terminal lobules and is reduced in a subset of epithelial cells during lactation.
      In contrast to observations for many homeobox genes in the mouse mammary gland in
      which homeobox gene expression is lost on neoplastic progression, IRX-2
      expression is maintained in human mammary neoplasias. Data suggest IRX-2
      functions in epithelial cell differentiation and demonstrate regulated expression
      during ductal and lobular proliferation as well as lactation.
FAU - Lewis, M T
AU  - Lewis MT
AD  - Department of Biology, Sinsheimer Laboratories, University of California, Santa
      Cruz, CA 95064, USA.
FAU - Ross, S
AU  - Ross S
FAU - Strickland, P A
AU  - Strickland PA
FAU - Snyder, C J
AU  - Snyder CJ
FAU - Daniel, C W
AU  - Daniel CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
RN  - 0 (Cytokines)
RN  - 0 (IRX 2)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Breast/cytology/*physiology
MH  - Breast Neoplasms/metabolism/pathology
MH  - Cell Differentiation
MH  - Cytokines/*biosynthesis/genetics
MH  - Epithelial Cells/cytology/physiology
MH  - Female
MH  - Gene Expression Regulation
MH  - *Genes, Homeobox
MH  - Humans
MH  - In Situ Hybridization
MH  - Lactation
MH  - Mice
MH  - Molecular Sequence Data
MH  - Sequence Alignment
EDAT- 1999/06/17 00:00
MHDA- 1999/06/17 00:01
CRDT- 1999/06/17 00:00
PHST- 1999/06/17 00:00 [pubmed]
PHST- 1999/06/17 00:01 [medline]
PHST- 1999/06/17 00:00 [entrez]
AID - 92960549.441 [pii]
AID - 10.1007/s004410051316 [doi]
PST - ppublish
SO  - Cell Tissue Res. 1999 Jun;296(3):549-54. doi: 10.1007/s004410051316.