PMID- 10366784
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20180213
IS  - 1018-8916 (Print)
IS  - 1018-8916 (Linking)
VI  - 16
IP  - 4
DP  - 1998
TI  - Lack of natural killer cell precursors in fetal liver of Ikaros knockout mutant
      mice.
PG  - 137-45
AB  - The role of Ikaros in early stages of natural killer (NK) cell differentiation
      was investigated using an in vitro system that promotes proliferation and
      differentiation of NK cell precursors into mature NK1.1+ cells. Day 14.5 fetal
      liver cells from mice, either homozygous for Ikaros Null or dominant negative
      (DN) mutations, had severe 55- to 79-fold reductions in functional NK cell
      precursors. Although there was no statistically significant difference between
      values for +/+ and +/- Null mice, the mean precursor frequency for DN mutant
      (+/-) mice was significantly above that for DN -/- mice and below that for DN +/+
      mice. The NK activity values for cells generated from the NK cell precursors
      followed the same respective relationships found for NK cell precursor
      frequencies. These data suggest that the deficiency of mature NK cells in Ikaros 
      mutant mice is related to lack of functional precursors.
FAU - Boggs, S S
AU  - Boggs SS
AD  - University of Pittsburgh School of Medicine and University of Pittsburgh Cancer
      Institute, Pittsburgh, PA 15261, USA. ssb1+@pitt.edu
FAU - Trevisan, M
AU  - Trevisan M
FAU - Patrene, K
AU  - Patrene K
FAU - Geogopoulos, K
AU  - Geogopoulos K
LA  - eng
GR  - CA55705/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Nat Immun
JT  - Natural immunity
JID - 9206126
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Zfpn1a1 protein, mouse)
RN  - 148971-36-2 (Ikaros Transcription Factor)
SB  - IM
MH  - Animals
MH  - *DNA-Binding Proteins
MH  - Female
MH  - Fetus/cytology/*immunology
MH  - Hematopoietic Stem Cells/*immunology
MH  - Heterozygote
MH  - Homozygote
MH  - Ikaros Transcription Factor
MH  - In Vitro Techniques
MH  - Killer Cells, Natural/*immunology
MH  - Liver/cytology/*immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Pregnancy
MH  - Transcription Factors/deficiency/*genetics/*immunology
EDAT- 1999/06/15 00:00
MHDA- 2001/10/12 10:01
CRDT- 1999/06/15 00:00
PHST- 1999/06/15 00:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 1999/06/15 00:00 [entrez]
AID - 69438 [pii]
AID - 10.1159/000069438 [doi]
PST - ppublish
SO  - Nat Immun. 1998;16(4):137-45. doi: 10.1159/000069438.