PMID- 10366634
OWN - NLM
STAT- MEDLINE
DCOM- 19990628
LR  - 20191210
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 12
DP  - 1999 Jun 15
TI  - Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and
      stress: differential roles of CRF receptors 1 and 2.
PG  - 5016-25
AB  - The differential modulation of learning and anxiety by corticotropin-releasing
      factor (CRF) through CRF receptor subtypes 1 (CRFR1) and 2 (CRFR2) is
      demonstrated. As learning paradigm, context- and tone-dependent fear conditioning
      of the mouse was used. Injection of CRF into the dorsal hippocampus before
      training enhanced learning through CRFR1 as demonstrated by the finding that this
      effect was prevented by the local injection of the unselective CRFR antagonist
      astressin, but not by the CRFR2-specific antagonist antisauvagine-30
      (anti-Svg-30). In contrast, injection of CRF into the lateral intermediate septum
      impaired learning through CRFR2, as demonstrated by the ability of
      antisauvagine-30 to block this effect. When antisauvagine-30 was injected alone
      into the lateral intermediate septum, learning was enhanced. Such tonic control
      of learning was not observed when astressin or antisauvagine-30 was injected into
      the dorsal hippocampus. Injection of CRF after the training into the dorsal
      hippocampus and the lateral intermediate septum also enhanced and impaired
      learning, respectively. Thus, it was indicated that CRF acted on memory
      consolidation. It was concluded that the observed effects reflected changes of
      associative learning and not arousal, attention, or motivation. Although a dose
      of 20 pmol human/rat CRF was sufficient to affect learning significantly, a
      fivefold higher dose was required to induce anxiety by injection into the septum.
      Immobilization for 1 hr generated a stress response that included the induction
      of anxiety through septal CRFR2 and the subsequent enhancement of learning
      through hippocampal CRFR1. The involvement of either receptor subtype was
      demonstrated by region-specific injections of astressin and antisauvagine-30.
FAU - Radulovic, J
AU  - Radulovic J
AD  - Max Planck Institute for Experimental Medicine, Department for Molecular
      Neuroendocrinology, 37075 Goettingen, Germany.
FAU - Ruhmann, A
AU  - Ruhmann A
FAU - Liepold, T
AU  - Liepold T
FAU - Spiess, J
AU  - Spiess J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for
      Neuroscience
JID - 8102140
RN  - 0 (CRF receptor type 2)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (antisauvagine 30)
RN  - 170809-51-5 (astressin)
RN  - 5CLY6W2H1M (CRF receptor type 1)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Anxiety/*physiopathology
MH  - Behavior, Animal/drug effects/physiology
MH  - Brain Chemistry/physiology
MH  - Conditioning, Psychological/drug effects/*physiology
MH  - Corticotropin-Releasing Hormone/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Fear/physiology
MH  - Hippocampus/chemistry/physiology
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neuroprotective Agents/pharmacology
MH  - Peptide Fragments/pharmacology
MH  - Receptors, Corticotropin-Releasing Hormone/agonists/antagonists &
      inhibitors/*physiology
MH  - Septal Nuclei/chemistry/physiology
MH  - Stress, Psychological/*physiopathology
PMC - PMC6782638
EDAT- 1999/06/15 00:00
MHDA- 1999/06/15 00:01
CRDT- 1999/06/15 00:00
PHST- 1999/06/15 00:00 [pubmed]
PHST- 1999/06/15 00:01 [medline]
PHST- 1999/06/15 00:00 [entrez]
PST - ppublish
SO  - J Neurosci. 1999 Jun 15;19(12):5016-25.