PMID- 10366590
OWN - NLM
STAT- MEDLINE
DCOM- 19990712
LR  - 20190508
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 145
IP  - 6
DP  - 1999 Jun 14
TI  - p24 proteins and quality control of LIN-12 and GLP-1 trafficking in
      Caenorhabditis elegans.
PG  - 1165-75
AB  - Mutations in the Caenorhabditis elegans sel-9 gene elevate the activity of lin-12
      and glp-1, which encode members of the LIN-12/NOTCH family of receptors. Sequence
      analysis indicates SEL-9 is one of several C. elegans p24 proteins.
      Allele-specific genetic interactions suggest that reducing sel-9 activity
      increases the activity of mutations altering the extracellular domains of LIN-12 
      or GLP-1. Reducing sel-9 activity restores the trafficking to the plasma membrane
      of a mutant GLP-1 protein that would otherwise accumulate within the cell. Our
      results suggest a role for SEL-9 and other p24 proteins in the negative
      regulation of transport of LIN-12 and GLP-1 to the cell surface, and favor a role
      for p24 proteins in a quality control mechanism for endoplasmic reticulum-Golgi
      transport.
FAU - Wen, C
AU  - Wen C
AD  - Department of Biochemistry and Molecular Biophysics, Columbia University, College
      of Physicians and Surgeons, New York, New York 10032, USA.
FAU - Greenwald, I
AU  - Greenwald I
LA  - eng
GR  - GM37602/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Glp-1 protein, C elegans)
RN  - 0 (Helminth Proteins)
RN  - 0 (Lin-12 protein, C elegans)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Notch)
RN  - 0 (SEL-9 protein, C elegans)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Animals
MH  - Biological Transport
MH  - Caenorhabditis elegans/cytology/genetics/*metabolism
MH  - *Caenorhabditis elegans Proteins
MH  - Cell Lineage
MH  - Cell Membrane/metabolism
MH  - Cloning, Molecular
MH  - Disorders of Sex Development
MH  - Endoplasmic Reticulum/chemistry/metabolism
MH  - Genes, Helminth/genetics/physiology
MH  - Genes, Lethal/genetics
MH  - Golgi Apparatus/chemistry/metabolism
MH  - Helminth Proteins/chemistry/genetics/*metabolism/*physiology
MH  - Membrane Glycoproteins/genetics/*metabolism
MH  - Membrane Proteins/genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phenotype
MH  - Receptors, Notch
MH  - Sequence Homology, Amino Acid
MH  - Stem Cells/cytology
MH  - Suppression, Genetic/genetics
PMC - PMC2133156
EDAT- 1999/06/15 00:00
MHDA- 1999/06/15 00:01
CRDT- 1999/06/15 00:00
PHST- 1999/06/15 00:00 [pubmed]
PHST- 1999/06/15 00:01 [medline]
PHST- 1999/06/15 00:00 [entrez]
AID - 10.1083/jcb.145.6.1165 [doi]
PST - ppublish
SO  - J Cell Biol. 1999 Jun 14;145(6):1165-75. doi: 10.1083/jcb.145.6.1165.