PMID- 10366450
OWN - NLM
STAT- MEDLINE
DCOM- 19990816
LR  - 20131121
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 58
IP  - 2
DP  - 1999 Jun 1
TI  - Characterization of MAD2B and other mitotic spindle checkpoint genes.
PG  - 181-7
AB  - Aneuploidy is a characteristic of the majority of human cancers, and recent work 
      has suggested that mitotic checkpoint defects play a role in its development. To 
      further explore this issue, we isolated a novel human gene, MAD2B (MAD2L2), which
      is homologous to the spindle checkpoint gene MAD2 (MAD2L1). We determined the
      chromosomal localization of it and other spindle checkpoint genes, including
      MAD1L1, MAD2, BUB3, TTK (MPS1L1), and CDC20. In addition, we resolved the genomic
      intron-exon structure of the human BUB1 gene. We then searched for mutations in
      these genes in a panel of 19 aneuploid colorectal tumors. No new mutations were
      identified, suggesting that genes yet to be discovered are responsible for most
      of the checkpoint defects observed in aneuploid cancers.
CI  - Copyright 1999 Academic Press.
FAU - Cahill, D P
AU  - Cahill DP
AD  - Program in Human Genetics, Johns Hopkins University School of Medicine,
      Baltimore, Maryland, 21231, USA.
FAU - da Costa, L T
AU  - da Costa LT
FAU - Carson-Walter, E B
AU  - Carson-Walter EB
FAU - Kinzler, K W
AU  - Kinzler KW
FAU - Vogelstein, B
AU  - Vogelstein B
FAU - Lengauer, C
AU  - Lengauer C
LA  - eng
SI  - GENBANK/AF139349
SI  - GENBANK/AF139350
SI  - GENBANK/AF139351
SI  - GENBANK/AF139352
SI  - GENBANK/AF139353
SI  - GENBANK/AF139354
SI  - GENBANK/AF139355
SI  - GENBANK/AF139356
SI  - GENBANK/AF139357
SI  - GENBANK/AF139358
SI  - GENBANK/AF139359
SI  - GENBANK/AF139360
SI  - GENBANK/AF139361
SI  - GENBANK/AF139362
SI  - GENBANK/AF139363
SI  - GENBANK/AF139364
SI  - GENBANK/AF139365
SI  - GENBANK/AH007963
GR  - CA43460/CA/NCI NIH HHS/United States
GR  - CA62924/CA/NCI NIH HHS/United States
GR  - GM07184/GM/NIGMS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA Primers)
RN  - 0 (MAD2L2 protein, human)
RN  - 0 (Mad2 Proteins)
RN  - 0 (Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Colonic Neoplasms/genetics
MH  - DNA Mutational Analysis
MH  - DNA Primers
MH  - Databases, Factual
MH  - Exons
MH  - Humans
MH  - Introns
MH  - Mad2 Proteins
MH  - Molecular Sequence Data
MH  - Physical Chromosome Mapping
MH  - Polymorphism, Genetic
MH  - Proteins/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Spindle Apparatus/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1999/06/15 00:00
MHDA- 1999/06/15 00:01
CRDT- 1999/06/15 00:00
PHST- 1999/06/15 00:00 [pubmed]
PHST- 1999/06/15 00:01 [medline]
PHST- 1999/06/15 00:00 [entrez]
AID - S0888-7543(99)95831-7 [pii]
AID - 10.1006/geno.1999.5831 [doi]
PST - ppublish
SO  - Genomics. 1999 Jun 1;58(2):181-7. doi: 10.1006/geno.1999.5831.