PMID- 10366448
OWN - NLM
STAT- MEDLINE
DCOM- 19990816
LR  - 20041117
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 58
IP  - 2
DP  - 1999 Jun 1
TI  - The third member of the transforming acidic coiled coil-containing gene family,
      TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and 
      is upregulated in various cancer cell lines.
PG  - 165-70
AB  - We have recently identified a novel gene, TACC1 (transforming acidic coiled
      coil-containing gene 1), which is located close to FGFR1 within a region
      amplified in breast cancer on human chromosome 8p11. The coiled coil domain of
      this gene identified a series of cDNAs in the expressed sequence tag database,
      which suggested the existence of a family of TACC genes comprising at least three
      family members. We have now characterized the human and mouse TACC3 cDNAs, and
      demonstrate that this gene is upregulated in various cancer cell lines, and at
      Embryonic Day 15 in mice, suggesting that the TACC3 protein is involved in the
      control of cell growth and differentiation. The TACC3 gene maps telomeric to the 
      FGFR3 gene in 4p16.3, close to a region disrupted by translocation breakpoints
      associated with multiple myeloma. Thus, TACC1, TACC2, and TACC3 map close to the 
      corresponding FGFR1, FGFR2, and FGFR3 genes. The phylogenetic relationship among 
      the three TACC genes is similar to that of the three FGFR family members. These
      relationships suggest that the FGFR and TACC genes arose from a physically linked
      ancestral gene pair. Subsequently, this gene pair has undergone two successive
      rounds of gene duplication to give rise to the three FGFR/TACC gene pairs on
      chromosomes 4, 8, and 10.
CI  - Copyright 1999 Academic Press.
FAU - Still, I H
AU  - Still IH
AD  - Center for Molecular Genetics, NB20, The Lerner Research Institute, Cleveland
      Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA.
      stilli@cesmtp.ccf.org
FAU - Vince, P
AU  - Vince P
FAU - Cowell, J K
AU  - Cowell JK
LA  - eng
SI  - GENBANK/AF093542
SI  - GENBANK/AF093543
PT  - Journal Article
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (TACC3 protein, human)
SB  - IM
MH  - Animals
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 4
MH  - Cloning, Molecular
MH  - Evolution, Molecular
MH  - Gene Library
MH  - Humans
MH  - Mice
MH  - *Microtubule-Associated Proteins
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Multiple Myeloma/*genetics
MH  - Neoplasm Proteins/*genetics/*metabolism
MH  - Phylogeny
MH  - Tumor Cells, Cultured
MH  - *Up-Regulation
EDAT- 1999/06/15 00:00
MHDA- 1999/06/15 00:01
CRDT- 1999/06/15 00:00
PHST- 1999/06/15 00:00 [pubmed]
PHST- 1999/06/15 00:01 [medline]
PHST- 1999/06/15 00:00 [entrez]
AID - S0888-7543(99)95829-9 [pii]
AID - 10.1006/geno.1999.5829 [doi]
PST - ppublish
SO  - Genomics. 1999 Jun 1;58(2):165-70. doi: 10.1006/geno.1999.5829.