PMID- 10366038
OWN - NLM
STAT- MEDLINE
DCOM- 19990803
LR  - 20061115
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 108
IP  - 1
DP  - 1999 Apr 1
TI  - Ageing and endocrine cells of human duodenum.
PG  - 39-48
AB  - Motility and secretory disorders of the gastrointestinal tract and associated
      glands increase with ageing. The duodenum contains several peptide/amine
      producing cells that play an important role in regulating gastrointestinal
      motility and secretion. The present study was performed to elucidate changes in
      these cells that may have arisen as a result of ageing. A total of four age
      groups of subjects, aged 1-2, 20-29, 40-49 and 60-69 years were studied. The
      various endocrine cell types were identified by immunohistochemistry and
      quantified by computerized image analysis, and two parameters were determined;
      the number of cells/mm3 epithelial cells and the cell secretory index (CSI),
      which indicates the immunoreactive secretory granule content of the endocrine
      cells. Chromogranin A- and serotonin-immunoreactive (IR) cells were fewer in
      1-2-year-olds than in 20-29-year-olds. Gastrin/CCK-IR cells were significantly
      more numerous in 1-2-year-olds and 60-69 years-olds than in 20-29-year-olds.
      Somatostatin-IR cells were more numerous in the 40-49-year-olds than in the 20-29
      years-olds. The CSI was higher in chromogranin A-, gastric inhibitory polypeptide
      (GIP)-, somatostatin- and gastrin/CCK-IR cells in 1-2-year-olds than in
      20-29-year-olds. There was no significant sex difference regarding the numbers
      and CSI of other endocrine cell types. This study established the absence of
      sex-related differences in all endocrine cell types investigated, regarding
      numbers and physiological activity. Age, on the other hand, was shown to be
      associated with changes in the numbers of CCK-, somatostatin- and serotonin-IR,
      which may have some bearing on the gastrointestinal disorders of the elderly.
FAU - Sandstrom, O
AU  - Sandstrom O
AD  - Department of Medicine, University Hospital, Umea, Sweden.
FAU - El-Salhy, M
AU  - El-Salhy M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*metabolism
MH  - Duodenum/cytology/*metabolism
MH  - Endoscopy, Gastrointestinal
MH  - Enteroendocrine Cells/cytology/*metabolism
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Immunoenzyme Techniques
MH  - Infant
MH  - Male
MH  - Middle Aged
EDAT- 1999/06/12 00:00
MHDA- 1999/06/12 00:01
CRDT- 1999/06/12 00:00
PHST- 1999/06/12 00:00 [pubmed]
PHST- 1999/06/12 00:01 [medline]
PHST- 1999/06/12 00:00 [entrez]
AID - S0047-6374(98)00154-7 [pii]
PST - ppublish
SO  - Mech Ageing Dev. 1999 Apr 1;108(1):39-48.