PMID- 10365852
OWN - NLM
STAT- MEDLINE
DCOM- 19990726
LR  - 20151119
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 49
IP  - 4
DP  - 1999 Apr
TI  - Expression of sialyl-Tn, Tn and T antigens in primary liver cancer.
PG  - 325-31
AB  - Sialyl-Tn, Tn and T antigens are caused by aberrant or incomplete glycosylation
      of apomucins and are related to the aggressiveness of malignant neoplasms. Using 
      41 liver samples from patients with cholangiocarcinoma (including four with
      cirrhosis), 21 with combined hepatocellular-cholangiocellular carcinoma and 17
      with hepatocellular carcinoma, the expression of sialyl-Tn, Tn and T antigens
      were characterized immunohistochemically and the correlation with apomucin
      profiles was evaluated. The prevalence of sialyl-Tn, Tn and T antigens expression
      was 89, 95 and 51% in cholangiocarcinoma without cirrhosis; 25, 75, and 0% in
      cholangiocarcinoma with cirrhosis; 29, 90, and 48% in combined
      hepatocellular-cholangiocellular carcinoma; and 0, 12 and 6% in hepatocellular
      carcinoma, respectively. Sialyl-Tn antigen was frequently expressed in
      cholangiocarcinoma without cirrhosis compared with cholangiocarcinoma with
      cirrhosis and combined hepatocellular-cholangiocellular carcinoma (P < 0.01).
      Although sialyl-Tn expression was associated with MUC1, MUC6 and MUC7 expression,
      the expression sites among them were not identical in the individual cases. These
      data suggest that the different expressions of sialyl-Tn antigen among
      cholangiocarcinoma without cirrhosis, cholangiocarcinoma with cirrhosis and
      combined hepatocellular-cholangiocellular carcinoma may reflect the biological
      features inherent to these tumors, such as the ability of invasion.
FAU - Sasaki, M
AU  - Sasaki M
AD  - Department of Pathology (II), Kanazawa University School of Medicine, Japan.
      msasaki@scarlet.ucdavis.edu
FAU - Yamato, T
AU  - Yamato T
FAU - Nakanuma, Y
AU  - Nakanuma Y
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Antigens, Tumor-Associated, Carbohydrate)
RN  - 0 (Antigens, Viral, Tumor)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Mucins)
RN  - 0 (Tn antigen)
RN  - 0 (sialosyl-Tn antigen)
SB  - IM
MH  - Antigens, Tumor-Associated, Carbohydrate/*biosynthesis
MH  - Antigens, Viral, Tumor/*biosynthesis
MH  - Biomarkers, Tumor/biosynthesis
MH  - Carcinoma, Hepatocellular/*metabolism
MH  - Cholangiocarcinoma/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver Cirrhosis/metabolism
MH  - Liver Neoplasms/*metabolism
MH  - Mucins/metabolism
EDAT- 1999/06/12 00:00
MHDA- 1999/06/12 00:01
CRDT- 1999/06/12 00:00
PHST- 1999/06/12 00:00 [pubmed]
PHST- 1999/06/12 00:01 [medline]
PHST- 1999/06/12 00:00 [entrez]
PST - ppublish
SO  - Pathol Int. 1999 Apr;49(4):325-31.