PMID- 10364457
OWN - NLM
STAT- MEDLINE
DCOM- 19990716
LR  - 20161124
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 259
IP  - 3
DP  - 1999 Jun 16
TI  - Identification of eukaryotic parvulin homologues: a new subfamily of
      peptidylprolyl cis-trans isomerases.
PG  - 557-62
AB  - We report here the existence of a subfamily of eukaryotic parvulin proteins that 
      have strong sequence homology with E. coli parvulin, but lack the WW domain found
      in previously described eukarytoic parvulins. We hence term members of this
      subfamily EPVH (eukaryotic parvulin homologue). We describe the characterisation 
      of hEPVH (human eukaryotic parvulin homologue). Immunogold labelling transmission
      electron microscopy reveals that hEPVH is preferentially localised in the
      mitochondrial matrix. The homology of hEPVH with its prokaryotic ancestor
      supports the hypothesis that this protein may have a mitochondrial function. An
      essential role in this organelle may explain the need for a high degree of
      conservation of this protein between distantly related species.
CI  - Copyright 1999 Academic Press.
FAU - Rulten, S
AU  - Rulten S
AD  - Department of Biological Sciences, University of Sussex, Falmer, Brighton, BN1
      9QG, United Kingdom.
FAU - Thorpe, J
AU  - Thorpe J
FAU - Kay, J
AU  - Kay J
LA  - eng
SI  - GENBANK/AF143096
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (NIMA-Interacting Peptidylprolyl Isomerase)
RN  - EC 5.2.1.8 (PIN1 protein, human)
RN  - EC 5.2.1.8 (Peptidylprolyl Isomerase)
RN  - EC 5.2.1.8 (parvA protein, E coli)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Line
MH  - Escherichia coli/chemistry
MH  - Escherichia coli Proteins
MH  - Humans
MH  - Molecular Sequence Data
MH  - NIMA-Interacting Peptidylprolyl Isomerase
MH  - Peptidylprolyl Isomerase/analysis/*chemistry/*classification
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
EDAT- 1999/06/12 00:00
MHDA- 1999/06/12 00:01
CRDT- 1999/06/12 00:00
PHST- 1999/06/12 00:00 [pubmed]
PHST- 1999/06/12 00:01 [medline]
PHST- 1999/06/12 00:00 [entrez]
AID - 10.1006/bbrc.1999.0828 [doi]
AID - S0006-291X(99)90828-8 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Jun 16;259(3):557-62. doi:
      10.1006/bbrc.1999.0828.