PMID- 10363996
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20191210
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 11
DP  - 1999 Jun 1
TI  - Characterization of a novel receptor that maps near the natural killer gene
      complex: demonstration of carbohydrate binding and expression in hematopoietic
      cells.
PG  - 2709-17
AB  - A novel type II integral membrane protein has been identified in the course of
      screening for genes overexpressed in a mouse model of chronic myelogenous
      leukemia blast crisis. This new protein, designated NKCL, consists of a 210-amino
      acid polypeptide with a short, NH2-terminal cytoplasmic tail of 17 amino acids
      preceding a transmembrane domain and a COOH-terminal extracellular region. The
      COOH-terminal 132 amino acids bear typical features of the C-type animal lectin
      carbohydrate-recognition domain. The Nkcl gene is unique in that it maps just
      proximal to the region of the genome that encodes group V members of the C-type
      animal lectin family near the natural killer gene complex on mouse chromosome 6, 
      but its protein product also has features of several group II C-type animal
      lectins. Most notably, it has a complete Ca2+-binding site 2, which forms part of
      the sugar-binding site in other members of the family, and binds mannose in a
      Ca2+-dependent manner. Moreover, its expression is not restricted to natural
      killer cells, as reported for the majority of group V lectins. Nkcl is expressed 
      in pluripotent myeloid precursors, precursor and mature macrophages, and
      neutrophils.
FAU - Fernandes, M J
AU  - Fernandes MJ
AD  - Thomas Jefferson University, Department of Microbiology and Immunology, Kimmel
      Cancer Institute, Philadelphia, Pennsylvania 19107, USA.
FAU - Finnegan, A A
AU  - Finnegan AA
FAU - Siracusa, L D
AU  - Siracusa LD
FAU - Brenner, C
AU  - Brenner C
FAU - Iscove, N N
AU  - Iscove NN
FAU - Calabretta, B
AU  - Calabretta B
LA  - eng
GR  - CA21124/CA/NCI NIH HHS/United States
GR  - CA46782/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Clec4n protein, mouse)
RN  - 0 (Lectins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blast Crisis/*genetics
MH  - Blotting, Northern
MH  - COS Cells
MH  - Chromosome Mapping
MH  - Genetic Vectors/genetics
MH  - Hematopoietic Stem Cells/*metabolism
MH  - *Killer Cells, Natural
MH  - Lectins/*genetics/metabolism
MH  - *Lectins, C-Type
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Membrane Proteins/*genetics/metabolism
MH  - Mice
MH  - Microscopy, Fluorescence
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/*genetics/metabolism
MH  - Receptors, Cell Surface/*genetics/metabolism
MH  - Transfection
EDAT- 1999/06/11 00:00
MHDA- 1999/06/11 00:01
CRDT- 1999/06/11 00:00
PHST- 1999/06/11 00:00 [pubmed]
PHST- 1999/06/11 00:01 [medline]
PHST- 1999/06/11 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Jun 1;59(11):2709-17.