PMID- 10363639
OWN - NLM
STAT- MEDLINE
DCOM- 19990914
LR  - 20191024
IS  - 0301-4851 (Print)
IS  - 0301-4851 (Linking)
VI  - 26
IP  - 1-2
DP  - 1999 Apr
TI  - The proteasome-dependent proteolytic system.
PG  - 3-9
AB  - The 20S proteasome is an intriguingly large complex that acts as a proteolytic
      catalytic machine. Accumulating evidence indicates the existence of multiple
      factors capable of regulating the proteasome function. They are classified into
      two different categories, one type of regulator is PA700 or PA28 that is
      reversibly associated with the 20S proteasome to form enzymatically active
      proteasomes and the other type including a 300-kDa modulator and PI31 indirectly 
      influences proteasome activity perhaps by promoting or suppressing the assembly
      of the 20S proteasome with PA700 or PA28. Thus, there have been documented two
      types of proteasomes composed of a core catalytic proteasome and a pair of
      symmetrically disposed PA700 or PA28 regulatory particle. Moreover, the
      recently-identified proteasome containing both PA28 and PA700 appears to play a
      significant role in the ATP-dependent proteolytic pathway in cells, as can the
      26S proteasome which is known as a eukaryotic ATP-dependent protease.
FAU - Tanahashi, N
AU  - Tanahashi N
AD  - The Tokyo Metropolitan Institute of Medical Science, and CREST, Japan Science and
      Technology Corporation.
FAU - Kawahara, H
AU  - Kawahara H
FAU - Murakami, Y
AU  - Murakami Y
FAU - Tanaka, K
AU  - Tanaka K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Muscle Proteins)
RN  - 0 (PA700 proteasome activator)
RN  - 0 (PSME1 protein, human)
RN  - 0 (Proteins)
RN  - 0 (Ubiquitins)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 4.1.1.17 (Ornithine Decarboxylase)
SB  - IM
MH  - Adenosine Triphosphatases/metabolism
MH  - Cysteine Endopeptidases/chemistry/*metabolism
MH  - Humans
MH  - Multienzyme Complexes/chemistry/*metabolism
MH  - *Muscle Proteins
MH  - Ornithine Decarboxylase/metabolism
MH  - Proteasome Endopeptidase Complex
MH  - Proteins/*metabolism
MH  - Ubiquitins/metabolism
RF  - 36
EDAT- 1999/06/11 00:00
MHDA- 1999/06/11 00:01
CRDT- 1999/06/11 00:00
PHST- 1999/06/11 00:00 [pubmed]
PHST- 1999/06/11 00:01 [medline]
PHST- 1999/06/11 00:00 [entrez]
AID - 10.1023/a:1006909522731 [doi]
PST - ppublish
SO  - Mol Biol Rep. 1999 Apr;26(1-2):3-9. doi: 10.1023/a:1006909522731.