PMID- 10362251
OWN - NLM
STAT- MEDLINE
DCOM- 19990625
LR  - 20200306
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 18
DP  - 1999 May 6
TI  - Isolation and characterization of mammalian homologues of Caenorhabditis elegans 
      lin-7: localization at cell-cell junctions.
PG  - 2811-7
AB  - In Caenorhabditis elegans, the vulval induction is mediated by the let-23
      receptor tyrosine kinase (RTK)/ Ras signaling pathway. The precise localization
      of the let-23 RTK at the epithelial junctions is essential for the vulval
      induction, and requires three genes including lin-2, -7, and -10. The mammalian
      homologue of lin-2 has been identified as a protein interacting with a neuronal
      adhesion molecule, neurexin, and named CASK. CASK has recently been reported to
      interact with syndecans and an actin-binding protein, band 4.1, at epithelial and
      synaptic junctions, and to play central roles in the formation of cell-cell
      junctions. The product of C. elegans lin-7 directly interacts with let-23 RTK and
      localize it at epithelial junctions. Here, we report three rat homologues of
      lin-7 ubiquitously expressed in various tissues. These homologues are accumulated
      at the junctional complex region in cultured Madin-Darby canine kidney cells, and
      are also localized at the synaptic junctions in neurons. The mammalian homologues
      of lin-7 may be implicated in the formation of cell-cell junctions.
FAU - Irie, M
AU  - Irie M
AD  - Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, Kobe.
FAU - Hata, Y
AU  - Hata Y
FAU - Deguchi, M
AU  - Deguchi M
FAU - Ide, N
AU  - Ide N
FAU - Hirao, K
AU  - Hirao K
FAU - Yao, I
AU  - Yao I
FAU - Nishioka, H
AU  - Nishioka H
FAU - Takai, Y
AU  - Takai Y
LA  - eng
SI  - GENBANK/AF090133
SI  - GENBANK/AF090134
SI  - GENBANK/AF090135
SI  - GENBANK/AF090136
PT  - Journal Article
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Helminth Proteins)
RN  - 0 (LIN-7 protein, C elegans)
RN  - 0 (Lin7a protein, rat)
RN  - 0 (Lin7b protein, rat)
RN  - 0 (Lin7c protein, rat)
RN  - 0 (Membrane Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (lin-7-Bb protein, rat)
RN  - 0 (nrx-1 protein, C elegans)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - COS Cells/metabolism
MH  - Caenorhabditis elegans/genetics
MH  - Caenorhabditis elegans Proteins/*genetics/metabolism
MH  - Cell Adhesion Molecules, Neuronal/*genetics/metabolism
MH  - Cell Line
MH  - Dogs
MH  - Helminth Proteins/*genetics/metabolism
MH  - Intercellular Junctions/*genetics/metabolism
MH  - Kidney/cytology/metabolism
MH  - Membrane Proteins/*genetics/metabolism
MH  - Molecular Sequence Data
MH  - Neurons/cytology/*metabolism
MH  - Rabbits
MH  - Rats
MH  - Recombinant Proteins/genetics/metabolism
MH  - Signal Transduction/genetics
MH  - Synapses/metabolism
MH  - Transfection
EDAT- 1999/06/11 00:00
MHDA- 1999/06/11 00:01
CRDT- 1999/06/11 00:00
PHST- 1999/06/11 00:00 [pubmed]
PHST- 1999/06/11 00:01 [medline]
PHST- 1999/06/11 00:00 [entrez]
AID - 10.1038/sj.onc.1202652 [doi]
PST - ppublish
SO  - Oncogene. 1999 May 6;18(18):2811-7. doi: 10.1038/sj.onc.1202652.