PMID- 10360575
OWN - NLM
STAT- MEDLINE
DCOM- 19990616
LR  - 20220309
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 399
IP  - 6734
DP  - 1999 May 27
TI  - The homeobox gene Phox2b is essential for the development of autonomic neural
      crest derivatives.
PG  - 366-70
AB  - The sympathetic, parasympathetic and enteric ganglia are the main components of
      the peripheral autonomic nervous system, and are all derived from the neural
      crest. The factors needed for these structures to develop include the
      transcription factor Mash1, the glial-derived neurotrophic factor GNDF and its
      receptor subunits, and the neuregulin signalling system, each of which is
      essential for the differentiation and survival of subsets of autonomic neurons.
      Here we show that all autonomic ganglia fail to form properly and degenerate in
      mice lacking the homeodomain transcription factor Phox2b, as do the three cranial
      sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of
      the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the 
      expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression.
      Mutant ganglionic anlagen also fail to switch on the genes that encode two
      enzymes needed for the biosynthesis of the neurotransmitter noradrenaline,
      dopamine-beta-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b
      regulates the noradrenergic phenotype in vertebrates.
FAU - Pattyn, A
AU  - Pattyn A
AD  - Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology
      Institute of Marseille, CNRS/INSERM/Universite de la Meditterranee/AP de
      Marseille, France.
FAU - Morin, X
AU  - Morin X
FAU - Cremer, H
AU  - Cremer H
FAU - Goridis, C
AU  - Goridis C
FAU - Brunet, J F
AU  - Brunet JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Ascl1 protein, mouse)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Gdnf protein, mouse)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (NBPhox protein)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - EC 1.14.17.1 (Dopamine beta-Hydroxylase)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-3)
SB  - IM
MH  - Animals
MH  - Autonomic Nervous System/*embryology
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - DNA-Binding Proteins/metabolism
MH  - Dopamine beta-Hydroxylase/genetics
MH  - Enteric Nervous System/embryology/physiology
MH  - ErbB Receptors/genetics
MH  - Ganglia, Autonomic/embryology/physiology
MH  - Ganglia, Sensory/embryology/physiology
MH  - Gene Expression
MH  - Gene Targeting
MH  - *Genes, Homeobox
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Homeodomain Proteins/*genetics/*physiology
MH  - Mice
MH  - Mutagenesis, Insertional
MH  - *Nerve Growth Factors
MH  - Nerve Tissue Proteins/genetics
MH  - Neural Crest/cytology/*embryology/physiology
MH  - Proto-Oncogene Proteins/genetics
MH  - Receptor, ErbB-3
MH  - Transcription Factors/*genetics/metabolism/*physiology
MH  - Tyrosine 3-Monooxygenase/genetics
EDAT- 1999/06/09 10:00
MHDA- 2001/03/23 10:01
CRDT- 1999/06/09 10:00
PHST- 1999/06/09 10:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/06/09 10:00 [entrez]
AID - 10.1038/20700 [doi]
PST - ppublish
SO  - Nature. 1999 May 27;399(6734):366-70. doi: 10.1038/20700.