PMID- 10359848
OWN - NLM
STAT- MEDLINE
DCOM- 19990726
LR  - 20190506
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 27
IP  - 12
DP  - 1999 Jun 15
TI  - Identification of a novel Sry-related gene and its germ cell-specific expression.
PG  - 2503-10
AB  - Sox family proteins are characterized by a unique DNA-binding domain, a HMG box
      which shows at least 50% sequence similarity with mouse Sry, the sex-determining 
      factor. At present almost 30 Sox genes have been identified. Members of this
      family have been shown to be conserved during evolution and to play key roles
      during animal development. Some are involved in human diseases, including sex
      reversal. Here we report the isolation of a novel member of the Sox gene family, 
      Sox30, which may constitute a distinct subgroup of this family. Using a
      bacterially expressed DNA-binding domain of Sox30, we show that it is able to
      specifically recognize the ACAAT motif. Furthermore, Sox30 is capable of
      activating transcription from a synthetic promoter containing the ACAAT motif.
      The specific expression of Sox30 in normal testes, but not in maturing germ
      cell-deficient testes, suggests the involvement of Sox30 in differentiation of
      male germ cells. Mapping analyses revealed that the Sox30 gene is located on
      human chromosome 5 (5q33) and on mouse chromosome 11.
FAU - Osaki, E
AU  - Osaki E
AD  - Department of Cellular and Molecular Biology, The Institute of Medical Science,
      University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
FAU - Nishina, Y
AU  - Nishina Y
FAU - Inazawa, J
AU  - Inazawa J
FAU - Copeland, N G
AU  - Copeland NG
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Ohsugi, M
AU  - Ohsugi M
FAU - Tezuka, T
AU  - Tezuka T
FAU - Yoshida, M
AU  - Yoshida M
FAU - Semba, K
AU  - Semba K
LA  - eng
SI  - GENBANK/AB022083
SI  - GENBANK/AB022441
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (SOX Transcription Factors)
RN  - 0 (SOX30 protein, human)
RN  - 0 (SOXB2 Transcription Factors)
RN  - 0 (SRY protein, human)
RN  - 0 (Sex-Determining Region Y Protein)
RN  - 0 (Sry protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (sox21a protein, zebrafish)
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 5
MH  - DNA-Binding Proteins/chemistry/*genetics/*isolation & purification/metabolism
MH  - High Mobility Group Proteins/genetics/*isolation & purification
MH  - Humans
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - *Nuclear Proteins
MH  - *SOX Transcription Factors
MH  - SOXB2 Transcription Factors
MH  - Sex-Determining Region Y Protein
MH  - Spermatozoa/*metabolism
MH  - Testis/cytology/*metabolism
MH  - *Transcription Factors
MH  - Transcriptional Activation
MH  - *Tumor Suppressor Proteins
MH  - *Zebrafish Proteins
PMC - PMC148454
EDAT- 1999/06/09 00:00
MHDA- 1999/06/09 00:01
CRDT- 1999/06/09 00:00
PHST- 1999/06/09 00:00 [pubmed]
PHST- 1999/06/09 00:01 [medline]
PHST- 1999/06/09 00:00 [entrez]
AID - gkc398.htm [pii]
AID - 10.1093/nar/27.12.2503 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 1999 Jun 15;27(12):2503-10. doi: 10.1093/nar/27.12.2503.