PMID- 10359701
OWN - NLM
STAT- MEDLINE
DCOM- 19990720
LR  - 20190728
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 9
IP  - 11
DP  - 1999 Jun 3
TI  - Suckling defect in mice lacking the soluble haemopoietin receptor NR6.
PG  - 605-8
AB  - Cytokines control a variety of cellular responses including proliferation,
      differentiation, survival and functional activation, via binding to specific
      receptors expressed on the surface of target cells [1]. The cytokine receptors of
      the haemopoietin family are defined by the presence of a conserved 200 amino acid
      extracellular domain known as the haemopoietin domain [2]. We report here the
      isolation of NR6, a haemopoietin receptor that, like the p40 subunit of
      interleukin-12 (IL-12) [3] and the EBI3 gene induced by Epstein-Barr virus
      infection in lymphocytes [4], contains a typical haemopoietin domain but lacks
      transmembrane and cytoplasmic domains. Although in situ hybridisation revealed
      NR6 expression at multiple sites in the developing embryo, mice lacking NR6 did
      not display obvious abnormalities and were born in the expected numbers. Neonatal
      NR6(-/-) mice failed to suckle, however, and died within 24 hours of birth,
      suggesting that NR6 is necessary for the recognition or processing of pheromonal 
      signals or for the mechanics of suckling itself. In addition, NR6(-/-) mice had
      reduced numbers of haemopoietic progenitor cells, suggesting a potential role in 
      the regulation of primitive haemopoiesis.
FAU - Alexander, W S
AU  - Alexander WS
AD  - The Walter and Eliza Hall Institute of Medical Research, The Cooperative Research
      Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital,
      Victoria, 3050, Australia. alexander_w@wehi.edu.au
FAU - Rakar, S
AU  - Rakar S
FAU - Robb, L
AU  - Robb L
FAU - Farley, A
AU  - Farley A
FAU - Willson, T A
AU  - Willson TA
FAU - Zhang, J G
AU  - Zhang JG
FAU - Hartley, L
AU  - Hartley L
FAU - Kikuchi, Y
AU  - Kikuchi Y
FAU - Kojima, T
AU  - Kojima T
FAU - Nomura, H
AU  - Nomura H
FAU - Hasegawa, M
AU  - Hasegawa M
FAU - Maeda, M
AU  - Maeda M
FAU - Fabri, L
AU  - Fabri L
FAU - Jachno, K
AU  - Jachno K
FAU - Nash, A
AU  - Nash A
FAU - Metcalf, D
AU  - Metcalf D
FAU - Nicola, N A
AU  - Nicola NA
FAU - Hilton, D J
AU  - Hilton DJ
LA  - eng
GR  - CA22556/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Carrier Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Leptin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Animals, Suckling/*physiology
MH  - Carrier Proteins/genetics/*physiology
MH  - Gene Expression Regulation, Developmental
MH  - Hematopoiesis/*physiology
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - *Receptors, Cell Surface
MH  - Receptors, Leptin
MH  - Sequence Homology, Amino Acid
MH  - Solubility
EDAT- 1999/06/09 00:00
MHDA- 1999/06/09 00:01
CRDT- 1999/06/09 00:00
PHST- 1999/06/09 00:00 [pubmed]
PHST- 1999/06/09 00:01 [medline]
PHST- 1999/06/09 00:00 [entrez]
AID - S0960-9822(99)80266-8 [pii]
AID - 10.1016/s0960-9822(99)80266-8 [doi]
PST - ppublish
SO  - Curr Biol. 1999 Jun 3;9(11):605-8. doi: 10.1016/s0960-9822(99)80266-8.