PMID- 10359593
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20181113
IS  - 1059-1524 (Print)
IS  - 1059-1524 (Linking)
VI  - 10
IP  - 6
DP  - 1999 Jun
TI  - Cloning and characterization of peter pan, a novel Drosophila gene required for
      larval growth.
PG  - 1733-44
AB  - We identified a new Drosophila gene, peter pan (ppan), in a screen for larval
      growth-defective mutants. ppan mutant larvae do not grow and show minimal DNA
      replication but can survive until well after their heterozygotic siblings have
      pupariated. We cloned the ppan gene by P-element plasmid rescue. ppan belongs to 
      a highly conserved gene family that includes Saccharomyces cerevisiae SSF1 and
      SSF2, as well as Schizosaccharomyces pombe, Arabidopsis, Caenorhabditis elegans, 
      mouse, and human homologues. Deletion of both SSF1 and SSF2 in yeast is lethal,
      and depletion of the gene products causes cell division arrest. Mosaic analysis
      of ppan mutant clones in Drosophila imaginal disks and ovaries demonstrates that 
      ppan is cell autonomous and required for normal mitotic growth but is not
      absolutely required for general biosynthesis or DNA replication. Overexpression
      of the wild-type gene causes cell death and disrupts the normal development of
      adult structures. The ppan gene family appears to have an essential and
      evolutionarily conserved role in cell growth.
FAU - Migeon, J C
AU  - Migeon JC
AD  - Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle,
      Washington 98109, USA.
FAU - Garfinkel, M S
AU  - Garfinkel MS
FAU - Edgar, B A
AU  - Edgar BA
LA  - eng
SI  - GENBANK/AF043700
SI  - GENBANK/AF102805
SI  - GENBANK/P38789
SI  - GENBANK/Q12153
SI  - GENBANK/Z98531
GR  - GM-51186/GM/NIGMS NIH HHS/United States
GR  - F32 GM017983/GM/NIGMS NIH HHS/United States
GR  - HG-00176/HG/NHGRI NIH HHS/United States
GR  - F32 HG000176/HG/NHGRI NIH HHS/United States
GR  - GM-17983/GM/NIGMS NIH HHS/United States
GR  - R01 GM051186/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Biol Cell
JT  - Molecular biology of the cell
JID - 9201390
RN  - 0 (Drosophila Proteins)
RN  - 0 (Growth Substances)
RN  - 0 (Insect Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PPAN protein, human)
RN  - 0 (SSF1 protein, S cerevisiae)
RN  - 0 (SSF2 protein, S cerevisiae)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (ppan protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - DNA Replication
MH  - Drosophila/*genetics/*growth & development
MH  - *Drosophila Proteins
MH  - Female
MH  - G1 Phase/genetics
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Suppressor
MH  - Growth Substances/*genetics/*metabolism
MH  - Humans
MH  - Insect Proteins/*genetics
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Larva/genetics/growth & development
MH  - Mice
MH  - Mitosis
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Nuclear Proteins/genetics
MH  - Oogenesis/genetics
MH  - Saccharomyces cerevisiae/genetics
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Homology, Amino Acid
PMC - PMC25365
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1091/mbc.10.6.1733 [doi]
PST - ppublish
SO  - Mol Biol Cell. 1999 Jun;10(6):1733-44. doi: 10.1091/mbc.10.6.1733.