PMID- 10359578
OWN - NLM
STAT- MEDLINE
DCOM- 19990708
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 189
IP  - 11
DP  - 1999 Jun 7
TI  - BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell
      growth.
PG  - 1747-56
AB  - Members of the tumor necrosis factor (TNF) family induce pleiotropic biological
      responses, including cell growth, differentiation, and even death. Here we
      describe a novel member of the TNF family, designated BAFF (for B cell activating
      factor belonging to the TNF family), which is expressed by T cells and dendritic 
      cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was
      processed and secreted through the action of a protease whose specificity matches
      that of the furin family of proprotein convertases. The expression of BAFF
      receptor appeared to be restricted to B cells. Both membrane-bound and soluble
      BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B
      lymphocytes. Moreover, increased amounts of immunoglobulins were found in
      supernatants of germinal center-like B cells costimulated with BAFF. These
      results suggest that BAFF plays an important role as costimulator of B cell
      proliferation and function.
FAU - Schneider, P
AU  - Schneider P
AD  - Institute of Biochemistry, University of Lausanne, Switzerland.
FAU - MacKay, F
AU  - MacKay F
FAU - Steiner, V
AU  - Steiner V
FAU - Hofmann, K
AU  - Hofmann K
FAU - Bodmer, J L
AU  - Bodmer JL
FAU - Holler, N
AU  - Holler N
FAU - Ambrose, C
AU  - Ambrose C
FAU - Lawton, P
AU  - Lawton P
FAU - Bixler, S
AU  - Bixler S
FAU - Acha-Orbea, H
AU  - Acha-Orbea H
FAU - Valmori, D
AU  - Valmori D
FAU - Romero, P
AU  - Romero P
FAU - Werner-Favre, C
AU  - Werner-Favre C
FAU - Zubler, R H
AU  - Zubler RH
FAU - Browning, J L
AU  - Browning JL
FAU - Tschopp, J
AU  - Tschopp J
LA  - eng
SI  - GENBANK/AF116456
SI  - GENBANK/AF119383
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (DNA Primers)
RN  - 0 (Ligands)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (TNFSF13B protein, human)
RN  - 0 (Tnfsf13b protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - B-Cell Activating Factor
MH  - B-Lymphocytes/cytology/*immunology
MH  - Base Sequence
MH  - Cell Division
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - Dendritic Cells/immunology
MH  - Humans
MH  - Ligands
MH  - Lymphocyte Activation
MH  - Membrane Proteins/genetics/*physiology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Receptors, Tumor Necrosis Factor/genetics/*physiology
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes/immunology
MH  - Tumor Necrosis Factor-alpha/genetics/*physiology
PMC - PMC2193079
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1084/jem.189.11.1747 [doi]
PST - ppublish
SO  - J Exp Med. 1999 Jun 7;189(11):1747-56. doi: 10.1084/jem.189.11.1747.