PMID- 10358772
OWN - NLM
STAT- MEDLINE
DCOM- 19990831
LR  - 20210103
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 17
DP  - 1999
TI  - The IL-4 receptor: signaling mechanisms and biologic functions.
PG  - 701-38
AB  - Interleukin-4 is a multifunctional cytokine that plays a critical role in the
      regulation of immune responses. Its effects depend upon binding to and signaling 
      through a receptor complex consisting of the IL-4R alpha chain and the common
      gamma chain (gamma c), resulting in a series of phosphorylation events mediated
      by receptor-associated kinases. In turn, these cause the recruitment of mediators
      of cell growth, of resistance to apoptosis, and of gene activation and
      differentiation. Here we describe our current understanding of the organization
      of the IL-4 receptor, of the signaling pathways that are induced as a result of
      receptor occupancy, and of the various mechanisms through which receptor function
      is modulated. We particularly emphasize the modular nature of the receptor and
      the specialization of different receptor regions for distinct functions, most
      notably the independent regulation of cell growth and gene activation.
FAU - Nelms, K
AU  - Nelms K
AD  - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Bethesda, MD 20892, USA.
FAU - Keegan, A D
AU  - Keegan AD
FAU - Zamorano, J
AU  - Zamorano J
FAU - Ryan, J J
AU  - Ryan JJ
FAU - Paul, W E
AU  - Paul WE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (IRS1 protein, human)
RN  - 0 (IRS2 protein, human)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Irs1 protein, mouse)
RN  - 0 (Irs2 protein, mouse)
RN  - 0 (Phosphoproteins)
RN  - 0 (Receptors, Interleukin-4)
RN  - 0 (STAT6 Transcription Factor)
RN  - 0 (STAT6 protein, human)
RN  - 0 (Stat6 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 207137-56-2 (Interleukin-4)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinases/immunology
MH  - Humans
MH  - Insulin Receptor Substrate Proteins
MH  - Interleukin-4/physiology
MH  - Intracellular Signaling Peptides and Proteins
MH  - JNK Mitogen-Activated Protein Kinases
MH  - Mice
MH  - Mice, Knockout
MH  - *Mitogen-Activated Protein Kinases
MH  - Molecular Sequence Data
MH  - Phosphoproteins/immunology
MH  - Protein Tyrosine Phosphatases/immunology
MH  - Receptors, Interleukin-4/chemistry/genetics/*physiology
MH  - STAT6 Transcription Factor
MH  - Signal Transduction
MH  - Trans-Activators/genetics/immunology
RF  - 183
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1146/annurev.immunol.17.1.701 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 1999;17:701-38. doi: 10.1146/annurev.immunol.17.1.701.