PMID- 10358769
OWN - NLM
STAT- MEDLINE
DCOM- 19990831
LR  - 20171116
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 17
DP  - 1999
TI  - Mechanisms of phagocytosis in macrophages.
PG  - 593-623
AB  - Phagocytosis of pathogens by macrophages initiates the innate immune response,
      which in turn orchestrates the adaptive response. In order to discriminate
      between infectious agents and self, macrophages have evolved a restricted number 
      of phagocytic receptors, like the mannose receptor, that recognize conserved
      motifs on pathogens. Pathogens are also phagocytosed by complement receptors
      after relatively nonspecific opsonization with complement and by Fc receptors
      after specific opsonization with antibodies. All these receptors induce
      rearrangements in the actin cytoskeleton that lead to the internalization of the 
      particle. However, important differences in the molecular mechanisms underlying
      phagocytosis by different receptors are now being appreciated. These include
      differences in the cytoskeletal elements that mediate ingestion, differences in
      vacuole maturation, and differences in inflammatory responses. Infectious agents,
      such as M. tuberculosis, Legionella pneumophila, and Salmonella typhimurium,
      enter macrophages via heterogeneous pathways and modify vacuolar maturation in a 
      manner that favors their survival. Macrophages also play an important role in the
      recognition and clearance of apoptotic cells; a notable feature of this process
      is the absence of an inflammatory response.
FAU - Aderem, A
AU  - Aderem A
AD  - Department of Immunology, University of Washington, Seattle 98195, USA.
      aaderem@u.washington.edu
FAU - Underhill, D M
AU  - Underhill DM
LA  - eng
GR  - AI25032/AI/NIAID NIH HHS/United States
GR  - AI32972/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Receptors, Complement)
RN  - 0 (Receptors, IgG)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Receptors, Vitronectin)
SB  - IM
MH  - Animals
MH  - Apoptosis/immunology
MH  - Caenorhabditis elegans/genetics/immunology
MH  - Humans
MH  - Legionella pneumophila/immunology
MH  - Lipopolysaccharide Receptors/metabolism
MH  - Macrophages/*immunology
MH  - Mycobacterium tuberculosis/immunology
MH  - Phagocytosis/*immunology
MH  - Receptors, Complement/metabolism
MH  - Receptors, IgG/metabolism
MH  - Receptors, Immunologic/immunology
MH  - Receptors, Scavenger
MH  - Receptors, Vitronectin/metabolism
MH  - Salmonella typhimurium/immunology
MH  - Vacuoles/immunology
RF  - 151
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1146/annurev.immunol.17.1.593 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 1999;17:593-623. doi: 10.1146/annurev.immunol.17.1.593.