PMID- 10358768
OWN - NLM
STAT- MEDLINE
DCOM- 19990831
LR  - 20091119
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 17
DP  - 1999
TI  - Genetic analysis of B cell antigen receptor signaling.
PG  - 555-92
AB  - In B lymphocytes, a signaling complex that contributes to cell fate decisions is 
      the B cell antigen receptor (BCR). Data from knockout experiments in cell lines
      and mice have revealed distinct functions for the intracellular protein tyrosine 
      kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of 
      intracellular signaling pathways downstream of these PTKs determine the quality
      and quantity of BCR signaling. For example, concerted actions of the PLC-gamma 2 
      and PI3-K pathways are required for proper calcium responses. Similarly, the
      regulation of ERK and JNK responses involves both PLC-gamma 2 and GTPases
      pathways. Since the immune response in vivo is regulated by alteration of these
      signaling outcomes, achieving a precise understanding of intracellular molecular 
      events leading to B lymphocyte proliferation, deletion, anergy, receptor editing,
      and survival still remains a challenge for the future.
FAU - Kurosaki, T
AU  - Kurosaki T
AD  - Department of Molecular Genetics, Kansai Medical University, Moriguchi, Japan.
      kurosaki@mxr.meshnet.or.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (Receptors, Antigen, B-Cell)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/cytology/*immunology/metabolism
MH  - Cell Differentiation
MH  - GTP-Binding Proteins/metabolism
MH  - Humans
MH  - Lipid Metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Models, Biological
MH  - Protein Tyrosine Phosphatases/genetics/metabolism
MH  - Protein-Serine-Threonine Kinases/metabolism
MH  - Protein-Tyrosine Kinases/genetics/metabolism
MH  - Receptors, Antigen, B-Cell/*genetics
MH  - Signal Transduction
RF  - 182
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1146/annurev.immunol.17.1.555 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 1999;17:555-92. doi: 10.1146/annurev.immunol.17.1.555.