PMID- 10358752
OWN - NLM
STAT- MEDLINE
DCOM- 19990831
LR  - 20061115
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 17
DP  - 1999
TI  - The multifaceted regulation of interleukin-15 expression and the role of this
      cytokine in NK cell differentiation and host response to intracellular pathogens.
PG  - 19-49
AB  - Interleukin-15 (IL-15) is a 14- to 15-kDa member of the 4 alpha-helix bundle
      family of cytokines. IL-15 expression is controlled at the levels of
      transcription, translation, and intracellular trafficking. In particular, IL-15
      protein is posttranscriptionally regulated by multiple controlling elements that 
      impede translation, including 12 upstream AUGs of the 5' UTR, 2 unusual signal
      peptides, and the C-terminus of the mature protein. IL-15 uses two distinct
      receptor and signaling pathways. In T and NK cells the IL-15 receptor includes
      IL-2/15R beta and gamma c subunits, which are shared with IL-2, and an
      IL-15-specific receptor subunit, IL-15R alpha. Mast cells respond to IL-15 with a
      receptor system that does not share elements with the IL-2 receptor but uses a
      novel 60- to 65-kDa IL-15RX subunit. In mast cells IL-15 signaling involves
      Jak2/STAT5 activation rather than the Jak1/Jak3 and STAT5/STAT3 system used in
      activated T cells. In addition to its other functional activities in immune and
      nonimmune cells, IL-15 plays a pivotal role in the development, survival, and
      function of NK cells. Abnormalities of IL-15 expression have been described in
      patients with rheumatoid arthritis or inflammatory bowel disease and in diseases 
      associated with the retroviruses HIV and HTLV-I. New approaches directed toward
      IL-15, its receptor, or its signaling pathway may be of value in the therapy of
      these disorders.
FAU - Waldmann, T A
AU  - Waldmann TA
AD  - Metabolism Branch, National Cancer Institute, National Institutes of Health,
      Bethesda, Maryland, USA. tawald@helix.nih.gov
FAU - Tagaya, Y
AU  - Tagaya Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (DNA, Complementary)
RN  - 0 (IL15RA protein, human)
RN  - 0 (Interleukin-15)
RN  - 0 (Receptors, Interleukin-15)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
SB  - X
MH  - Animals
MH  - Autoimmune Diseases/immunology
MH  - Base Sequence
MH  - Cell Differentiation
MH  - DNA, Complementary/genetics
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immunosuppression
MH  - Immunotherapy
MH  - Inflammation/immunology
MH  - Interleukin-15/*genetics/*physiology
MH  - Killer Cells, Natural/cytology/*immunology
MH  - Neoplasms/immunology
MH  - Receptors, Interleukin-15
MH  - Receptors, Interleukin-2/physiology
MH  - Retroviridae Infections/immunology
MH  - Signal Transduction
RF  - 142
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1146/annurev.immunol.17.1.19 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 1999;17:19-49. doi: 10.1146/annurev.immunol.17.1.19.