PMID- 10358138
OWN - NLM
STAT- MEDLINE
DCOM- 19990630
LR  - 20191115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 162
IP  - 12
DP  - 1999 Jun 15
TI  - Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein
      tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP.
PG  - 6981-5
AB  - The genetic defect in X-linked lymphoproliferative syndrome (XLP) is the Src
      homology 2 domain-containing protein SAP. SAP constitutively associates with the 
      cell surface molecule, signaling lymphocytic activation molecule (SLAM), and
      competes with SH2-domain containing protein tyrosine phosphatase-2 (SHP-2) for
      recruitment to SLAM. SLAM exhibits homology with the mouse cell surface receptor 
      2B4. The human homologue of 2B4 has now been identified. It is recognized by the 
      c1.7 mAb, a mAb capable of activating human NK cells. Human 2B4 became tyrosine
      phosphorylated following pervanadate-treatment of transfected cells and recruited
      SHP-2. SAP was also recruited to 2B4 in activated cells. Importantly, the 2B4-SAP
      interaction prevented the association between 2B4 and SHP-2. These results
      suggest that the phenotype of XLP may result from perturbed signaling not only
      through SLAM, but also other cell surface molecules that utilize SAP as a
      signaling adaptor protein.
FAU - Tangye, S G
AU  - Tangye SG
AD  - Department of Immunobiology, DNAX Research Institute of Molecular and Cellular
      Biology, Palo Alto, CA, USA.
FAU - Lazetic, S
AU  - Lazetic S
FAU - Woollatt, E
AU  - Woollatt E
FAU - Sutherland, G R
AU  - Sutherland GR
FAU - Lanier, L L
AU  - Lanier LL
FAU - Phillips, J H
AU  - Phillips JH
LA  - eng
SI  - GENBANK/AF145782
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD)
RN  - 0 (CD244 protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cd244a protein, mouse)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (SH2D1A protein, human)
RN  - 0 (Signaling Lymphocytic Activation Molecule Associated Protein)
RN  - 0 (Signaling Lymphocytic Activation Molecule Family)
RN  - EC 3.1.3.16 (Protein Phosphatase 2)
RN  - EC 3.1.3.48 (PTPN11 protein, human)
RN  - EC 3.1.3.48 (PTPN6 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 11)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 6)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.1.3.48 (Ptpn11 protein, mouse)
RN  - EC 3.1.3.48 (Ptpn6 protein, mouse)
RN  - EC 3.1.3.48 (SH2 Domain-Containing Protein Tyrosine Phosphatases)
SB  - AIM
SB  - IM
MH  - Amino Acid Sequence
MH  - Antibodies, Monoclonal/chemistry/metabolism
MH  - *Antigens, CD
MH  - Carrier Proteins/*metabolism
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - Enzyme Activation/immunology
MH  - Humans
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Killer Cells, Natural/*metabolism
MH  - Membrane Glycoproteins/chemistry/genetics/immunology/*physiology
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Protein Phosphatase 2
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 11
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 6
MH  - Protein Tyrosine Phosphatases/*metabolism
MH  - Receptors, Immunologic/chemistry/genetics/immunology/*physiology
MH  - SH2 Domain-Containing Protein Tyrosine Phosphatases
MH  - Signal Transduction/*immunology
MH  - Signaling Lymphocytic Activation Molecule Associated Protein
MH  - Signaling Lymphocytic Activation Molecule Family
MH  - src Homology Domains/*immunology
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1999 Jun 15;162(12):6981-5.