PMID- 10358072
OWN - NLM
STAT- MEDLINE
DCOM- 19990706
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 24
DP  - 1999 Jun 11
TI  - Identification of a novel gene family encoding human liver-specific organic anion
      transporter LST-1.
PG  - 17159-63
AB  - We have isolated a novel liver-specific organic anion transporter, LST-1, that is
      expressed exclusively in the human, rat, and mouse liver. LST-1 is a new gene
      family located between the organic anion transporter family and prostaglandin
      transporter. LST-1 transports taurocholate (Km = 13.6 microM) in a
      sodium-independent manner. LST-1 also shows broad substrate specificity. It
      transports conjugated steroids (dehydroepiandrosterone sulfate,
      estradiol-17beta-glucuronide, and estrone-3-sulfate), eicosanoids (prostaglandin 
      E2, thromboxane B2, leukotriene C4, leukotriene E4), and thyroid hormones
      (thyroxine, Km = 3.0 microM and triiodothyronine, Km = 2.7 microM), reflecting
      hepatic multispecificity. LST-1 is probably the most important transporter in
      human liver for clearance of bile acids and organic anions because hepatic levels
      of another organic anion transporter, OATP, is very low. This is also the first
      report of the human molecule that transports thyroid hormones.
FAU - Abe, T
AU  - Abe T
AD  - Department of Neurophysiology, Tohoku University School of Medicine, Sendai,
      980-8575, Tokyo, 140-8710, Japan. takaabe@mail.cc.tohoku.ac.jp
FAU - Kakyo, M
AU  - Kakyo M
FAU - Tokui, T
AU  - Tokui T
FAU - Nakagomi, R
AU  - Nakagomi R
FAU - Nishio, T
AU  - Nishio T
FAU - Nakai, D
AU  - Nakai D
FAU - Nomura, H
AU  - Nomura H
FAU - Unno, M
AU  - Unno M
FAU - Suzuki, M
AU  - Suzuki M
FAU - Naitoh, T
AU  - Naitoh T
FAU - Matsuno, S
AU  - Matsuno S
FAU - Yawo, H
AU  - Yawo H
LA  - eng
SI  - GENBANK/AF060500
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Anion Transport Proteins)
RN  - 0 (Arachidonic Acids)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cations)
RN  - 0 (DNA, Complementary)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Steroids)
RN  - 0 (Thyroid Hormones)
RN  - 5E090O0G3Z (Taurocholic Acid)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Anion Transport Proteins
MH  - Arachidonic Acids/metabolism
MH  - Biological Transport
MH  - Carrier Proteins/genetics/*metabolism
MH  - Cations/metabolism
MH  - DNA, Complementary/genetics
MH  - Humans
MH  - Liver/chemistry/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Rats
MH  - Recombinant Proteins/metabolism
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Steroids/metabolism
MH  - Taurocholic Acid/*metabolism
MH  - Thyroid Hormones/metabolism
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1074/jbc.274.24.17159 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Jun 11;274(24):17159-63. doi: 10.1074/jbc.274.24.17159.