PMID- 10358032
OWN - NLM
STAT- MEDLINE
DCOM- 19990706
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 24
DP  - 1999 Jun 11
TI  - RIP3, a novel apoptosis-inducing kinase.
PG  - 16871-5
AB  - RIP3 is a novel gene product containing a N-terminal kinase domain that shares
      extensive homology with the corresponding domain in RIP (receptor-interacting
      protein) and RIP2. Unlike RIP, which has a C-terminal death domain, and RIP2,
      which has a C-terminal caspase activation and recruitment domain, RIP3 has a
      unique C terminus. RIP3 binds RIP through its unique C-terminal segment and by
      virtue of this interaction is recruited to the tumor necrosis factor (TNF)
      receptor-1 signaling complex. Previous studies have shown that RIP mediates
      TNF-induced activation of the anti-apoptotic NF-kappaB pathway. RIP3, however,
      attenuates both RIP and TNF receptor-1-induced NF-kappaB activation.
      Overexpression studies revealed RIP3 to be a potent inducer of apoptosis, capable
      of selectively binding to large prodomain initiator caspases.
FAU - Sun, X
AU  - Sun X
AD  - Departments of Molecular Oncology, Genentech, Inc., South San Francisco,
      California 94080, USA.
FAU - Lee, J
AU  - Lee J
FAU - Navas, T
AU  - Navas T
FAU - Baldwin, D T
AU  - Baldwin DT
FAU - Stewart, T A
AU  - Stewart TA
FAU - Dixit, V M
AU  - Dixit VM
LA  - eng
SI  - GENBANK/AA227673
SI  - GENBANK/AI082587
SI  - GENBANK/AI394293
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Antigens, CD)
RN  - 0 (NF-kappa B)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (RIPK1 protein, human)
RN  - EC 2.7.11.1 (RIPK2 protein, human)
RN  - EC 2.7.11.1 (RIPK3 protein, human)
RN  - EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinase 2)
RN  - EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigens, CD/metabolism
MH  - *Apoptosis
MH  - Caspases/metabolism
MH  - Cloning, Molecular
MH  - Humans
MH  - Molecular Sequence Data
MH  - NF-kappa B/metabolism
MH  - Protein Binding
MH  - Protein Kinases/genetics/*metabolism
MH  - Protein-Serine-Threonine Kinases
MH  - Proteins/metabolism
MH  - Receptor-Interacting Protein Serine-Threonine Kinase 2
MH  - Receptor-Interacting Protein Serine-Threonine Kinases
MH  - Receptors, Tumor Necrosis Factor/metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Recombinant Proteins/metabolism
MH  - Sequence Analysis
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1074/jbc.274.24.16871 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Jun 11;274(24):16871-5. doi: 10.1074/jbc.274.24.16871.