PMID- 10357893
OWN - NLM
STAT- MEDLINE
DCOM- 19990715
LR  - 20061115
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 210
IP  - 2
DP  - 1999 Jun 15
TI  - Expression and genetic interaction of transcription factors GATA-2 and GATA-3
      during development of the mouse central nervous system.
PG  - 305-21
AB  - Here we examine the expression of transcription factors GATA-2 and GATA-3 during 
      early stages of embryonic development in the central nervous system (CNS) of the 
      mouse. GATA-2 is expressed as early as 9 dpc in the hindbrain, in ventral
      rhombomere 4, and transiently in ventral rhombomere 2 (r2). From 9.5 to 11.5 dpc,
      activation of the gene spreads to many sites of early neuronal differentiation,
      such as the olfactory bulbs, the pretectum, and the oculomotor nucleus in the
      midbrain, a thin stripe of cells lining the floor plate from the mesencephalon to
      the cervical spinal cord and a ventral column of cells spanning the neural tube
      from rostral hindbrain and including motor neuron as well as ventral interneuron 
      precursors. GATA-3 is expressed in a pattern very similar to that of GATA-2.
      Distinguishing features are the lack of expression in r2 at 9 dpc and a slight
      delay in its activation. In addition, GATA-2 is activated in both the ventricular
      and the subventricular zones of the neural tube, whereas GATA-3 is restricted
      mainly to the subventricular zone. Expression analyses performed on GATA-2 -/-
      mouse embryos between E9.5 and 10.5 dpc established that: (i) the expression of
      GATA-3 in the developing CNS of the mouse embryo is dependent on the presence of 
      GATA-2 and (ii) loss of GATA-2 leads to severe defects in neurogenesis, which
      strongly suggests that GATA-2 is involved, as in hematopoiesis, in the
      maintenance of the pool of ventral neuronal progenitors.
CI  - Copyright 1999 Academic Press.
FAU - Nardelli, J
AU  - Nardelli J
AD  - Cytosquelette et Developpement, CNRS URA 2115, CHU Pitie-Salpetriere, 105
      Boulevard de l'Hopital, Paris Cedex, 75 634, France. nardelli@idf.ext.jussieu.fr
FAU - Thiesson, D
AU  - Thiesson D
FAU - Fujiwara, Y
AU  - Fujiwara Y
FAU - Tsai, F Y
AU  - Tsai FY
FAU - Orkin, S H
AU  - Orkin SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (GATA2 Transcription Factor)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (Gata2 protein, mouse)
RN  - 0 (Gata3 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Brain/cytology/*embryology/metabolism
MH  - Cell Differentiation
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - *Embryonic and Fetal Development
MH  - GATA2 Transcription Factor
MH  - GATA3 Transcription Factor
MH  - *Gene Expression Regulation, Developmental
MH  - Gestational Age
MH  - Interneurons/cytology/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Neurons/cytology/physiology
MH  - Spinal Cord/cytology/*embryology/metabolism
MH  - Stem Cells/physiology
MH  - Trans-Activators/*genetics/metabolism
MH  - Transcription Factors/*genetics/metabolism
MH  - Zinc Fingers
EDAT- 1999/06/08 00:00
MHDA- 1999/06/08 00:01
CRDT- 1999/06/08 00:00
PHST- 1999/06/08 00:00 [pubmed]
PHST- 1999/06/08 00:01 [medline]
PHST- 1999/06/08 00:00 [entrez]
AID - 10.1006/dbio.1999.9278 [doi]
AID - S0012-1606(99)99278-3 [pii]
PST - ppublish
SO  - Dev Biol. 1999 Jun 15;210(2):305-21. doi: 10.1006/dbio.1999.9278.