PMID- 10357856
OWN - NLM
STAT- MEDLINE
DCOM- 19990701
LR  - 20181113
IS  - 1092-2172 (Print)
IS  - 1092-2172 (Linking)
VI  - 63
IP  - 2
DP  - 1999 Jun
TI  - Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and
      interrelationships with other steps in mRNA synthesis.
PG  - 405-45
AB  - Formation of mRNA 3' ends in eukaryotes requires the interaction of transacting
      factors with cis-acting signal elements on the RNA precursor by two distinct
      mechanisms, one for the cleavage of most replication-dependent histone
      transcripts and the other for cleavage and polyadenylation of the majority of
      eukaryotic mRNAs. Most of the basic factors have now been identified, as well as 
      some of the key protein-protein and RNA-protein interactions. This processing can
      be regulated by changing the levels or activity of basic factors or by using
      activators and repressors, many of which are components of the splicing
      machinery. These regulatory mechanisms act during differentiation, progression
      through the cell cycle, or viral infections. Recent findings suggest that the
      association of cleavage/polyadenylation factors with the transcriptional complex 
      via the carboxyl-terminal domain of the RNA polymerase II (Pol II) large subunit 
      is the means by which the cell restricts polyadenylation to Pol II transcripts.
      The processing of 3' ends is also important for transcription termination
      downstream of cleavage sites and for assembly of an export-competent mRNA. The
      progress of the last few years points to a remarkable coordination and
      cooperativity in the steps leading to the appearance of translatable mRNA in the 
      cytoplasm.
FAU - Zhao, J
AU  - Zhao J
AD  - Department of Molecular Biology and Microbiology, School of Medicine, Tufts
      University, Boston, Massachusetts 02111, USA.
FAU - Hyman, L
AU  - Hyman L
FAU - Moore, C
AU  - Moore C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Microbiol Mol Biol Rev
JT  - Microbiology and molecular biology reviews : MMBR
JID - 9706653
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.7.- (RNA Polymerase II)
SB  - IM
MH  - Alternative Splicing/genetics
MH  - Animals
MH  - Eukaryotic Cells/*physiology
MH  - Humans
MH  - RNA Polymerase II/genetics
MH  - RNA, Messenger/*biosynthesis
MH  - Transcription, Genetic/genetics
MH  - Transcriptional Activation
MH  - Yeasts/genetics/physiology
RF  - 518
PMC - PMC98971
EDAT- 1999/06/05 00:00
MHDA- 1999/06/05 00:01
CRDT- 1999/06/05 00:00
PHST- 1999/06/05 00:00 [pubmed]
PHST- 1999/06/05 00:01 [medline]
PHST- 1999/06/05 00:00 [entrez]
PST - ppublish
SO  - Microbiol Mol Biol Rev. 1999 Jun;63(2):405-45.