PMID- 10354473
OWN - NLM
STAT- MEDLINE
DCOM- 19990802
LR  - 20190909
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 82
IP  - 1-2
DP  - 1999 Apr
TI  - SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and 
      by Shh during development.
PG  - 79-94
AB  - We describe a novel chick WD-protein, cSWiP-1, expressed in somitic mesoderm and 
      developing limb buds as well as in other embryonic structures where Hedgehog
      signalling has been shown to play a role. Using embryonic manipulations we show
      that in somites cSWiP-1 expression integrates two signals originating from
      structures adjacent to the segmental mesoderm: a positive signal from the
      notochord and a negative signal from intermediate and/or lateral mesoderm. In
      explant cultures of somitic mesoderm, Shh protein induces cSWiP-1, while a
      blocking antibody to Shh inhibits the induction of cSWiP-1 by the notochord.
      These results show that the positive signal from the notochord is mediated by
      Shh. We also show that in limb buds cSWiP-1 is upregulated by ectopic Shh. This
      occurs in about the same time period as upregulation of BMP2, placing cSWiP-1
      among the earliest markers for the change of limb pattern caused by ectopic Shh. 
      We also describe a human homologue of cSWiP-1 and a mouse gene, mSWiP-2, that is 
      more distantly related to SWiP-1, suggesting that SWiP-1 belongs to a novel
      subfamily of WD-proteins.
FAU - Vasiliauskas, D
AU  - Vasiliauskas D
AD  - Department of Genetics and Development, College of Physicians and Surgeons of
      Columbia University, 701 West 168th Street, New York, NY 10032, USA.
FAU - Hancock, S
AU  - Hancock S
FAU - Stern, C D
AU  - Stern CD
LA  - eng
SI  - GENBANK/AF072879
SI  - GENBANK/AF072880
SI  - GENBANK/AF072881
GR  - HD31942/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (BMP2 protein, human)
RN  - 0 (Bmp2 protein, mouse)
RN  - 0 (Bone Morphogenetic Protein 2)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Proteins)
RN  - 0 (SHH protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (WSB1 protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bone Morphogenetic Protein 2
MH  - Bone Morphogenetic Proteins/metabolism
MH  - Chick Embryo
MH  - Embryonic Induction/genetics/physiology
MH  - Extremities/embryology
MH  - Gene Expression Regulation, Developmental
MH  - Hedgehog Proteins
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Notochord/embryology/metabolism
MH  - Proteins/genetics/*physiology
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Somites/cytology/metabolism
MH  - Species Specificity
MH  - *Trans-Activators
MH  - *Transforming Growth Factor beta
EDAT- 1999/06/04 00:00
MHDA- 1999/06/04 00:01
CRDT- 1999/06/04 00:00
PHST- 1999/06/04 00:00 [pubmed]
PHST- 1999/06/04 00:01 [medline]
PHST- 1999/06/04 00:00 [entrez]
AID - S0925477399000143 [pii]
AID - 10.1016/s0925-4773(99)00014-3 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Apr;82(1-2):79-94. doi: 10.1016/s0925-4773(99)00014-3.