PMID- 10353898
OWN - NLM
STAT- MEDLINE
DCOM- 19990708
LR  - 20210915
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 152
IP  - 2
DP  - 1999 Jun
TI  - Positive selection drives the evolution of the Acp29AB accessory gland protein in 
      Drosophila.
PG  - 543-51
AB  - Nucleotide sequence variation at the Acp29AB gene region has been surveyed in 
      Drosophila melanogaster from Spain (12 lines), Ivory Coast (14 lines), and Malawi 
      (13 lines) and in one line of D. simulans. The approximately 1.7-kb region 
      studied encompasses the Acp29AB gene that codes for a male accessory gland 
      protein and its flanking regions. Seventy-seven nucleotide and 8 length 
      polymorphisms were detected. Nonsynonymous polymorphism was an order of magnitude 
      lower than synonymous polymorphism, but still high relative to other 
      non-sex-related genes. In D. melanogaster variation at this region revealed no 
      major genetic differentiation between East and West African populations, while 
      differentiation was highly significant between the European and the two African 
      populations. Comparison of polymorphism and divergence at synonymous and 
      nonsynonymous sites showed an excess of fixed nonsynonymous changes, which 
      indicates that the evolution of the Acp29AB protein has been driven by 
      directional selection at least after the split of the D. melanogaster and D. 
      simulans lineages. The pattern of variation in extant populations of D. 
      melanogaster favors a scenario where the fixation of advantageous replacement 
      substitutions occurred in the early stages of speciation and balancing selection 
      is maintaining variation in this species.
FAU - Aguade, M
AU  - Aguade M
AD  - Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 08071 
      Barcelona, Spain. aguade@porthos.bio.ub.es
LA  - eng
SI  - GENBANK/AJ240513
SI  - GENBANK/AJ240514
SI  - GENBANK/AJ240515
SI  - GENBANK/AJ240516
SI  - GENBANK/AJ240517
SI  - GENBANK/AJ240518
SI  - GENBANK/AJ240519
SI  - GENBANK/AJ240520
SI  - GENBANK/AJ240521
SI  - GENBANK/AJ240522
SI  - GENBANK/AJ240523
SI  - GENBANK/AJ240524
SI  - GENBANK/AJ240525
SI  - GENBANK/AJ240526
SI  - GENBANK/AJ240527
SI  - GENBANK/AJ240528
SI  - GENBANK/AJ240529
SI  - GENBANK/AJ240530
SI  - GENBANK/AJ240531
SI  - GENBANK/AJ240532
SI  - GENBANK/AJ240533
SI  - GENBANK/AJ240534
SI  - GENBANK/AJ240535
SI  - GENBANK/AJ240536
SI  - GENBANK/AJ240537
SI  - GENBANK/AJ240538
SI  - GENBANK/AJ240539
SI  - GENBANK/AJ240540
SI  - GENBANK/AJ240541
SI  - GENBANK/AJ240542
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (Acp29AB protein, Drosophila)
RN  - 0 (Acp36DE protein, Drosophila)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Hormones)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Peptides)
RN  - 0 (SP protein, Drosophila)
RN  - 0 (male accessory gland peptide, Drosophila)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Amino Acid Substitution
MH  - Animals
MH  - Base Sequence
MH  - DNA/chemistry/genetics
MH  - Drosophila/*genetics
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/genetics
MH  - *Evolution, Molecular
MH  - Female
MH  - Genes, Insect/genetics
MH  - Genetic Variation
MH  - Haplotypes
MH  - Insect Hormones/*genetics
MH  - Intercellular Signaling Peptides and Proteins
MH  - Male
MH  - Molecular Sequence Data
MH  - Peptides/*genetics
MH  - Polymorphism, Genetic
MH  - *Selection, Genetic
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
PMC - PMC1460617
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - 10.1093/genetics/152.2.543 [doi]
PST - ppublish
SO  - Genetics. 1999 Jun;152(2):543-51. doi: 10.1093/genetics/152.2.543.