PMID- 10353607
OWN - NLM
STAT- MEDLINE
DCOM- 19990617
LR  - 20061115
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 16
DP  - 1999 Apr 22
TI  - Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is
      mapped to chromosome 14p11.
PG  - 2635-42
AB  - The fibroblast growth factors (FGFs) play crucial roles in controlling embryonic 
      development, cell growth, morphogenesis, and tissue repair in animals.
      Furthermore, FGFs may have a role in angiogenesis and may be involved in tumor
      invasion and metastasis. Here, we present the cloning and sequence of human
      FGF-18, a novel member of the FGF family. Sequence comparison indicates that
      FGF-18 is conserved with the other FGFs and most homologous to FGF-8 among the
      FGF family members. We showed that human FGF-18 was expressed primarily in the
      heart, skeletal muscle, and pancreas, and at lower levels in the other tissues.
      FGF-18 was also expressed at low levels in certain cancer cell lines. FGF-18
      contains a typical signal peptide and was secreted when it was transfected into
      mammalian cells. Recombinant FGF-18 protein stimulated proliferation in the
      fibroblast cell line NIH3T3 in a dose-dependent manner, suggesting that FGF-18 is
      a functional growth factor. Finally, the FGF-18 gene was evolutionarily
      conserved, and localized to human chromosome 14p11.
FAU - Hu, M C
AU  - Hu MC
AD  - Department of Cell Biology and Functional Genomics, Amgen Inc., Thousand Oaks,
      California 91320, USA.
FAU - Wang, Y P
AU  - Wang YP
FAU - Qiu, W R
AU  - Qiu WR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Recombinant Proteins)
RN  - 0 (fibroblast growth factor 18)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Division/drug effects
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 14
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - Fibroblast Growth Factors/*genetics/*pharmacology
MH  - Fibroblasts/*drug effects
MH  - Gene Dosage
MH  - Humans
MH  - Molecular Sequence Data
MH  - Recombinant Proteins/pharmacology
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - 10.1038/sj.onc.1202616 [doi]
PST - ppublish
SO  - Oncogene. 1999 Apr 22;18(16):2635-42. doi: 10.1038/sj.onc.1202616.