PMID- 10352231
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 232
IP  - 2
DP  - 1999 May 31
TI  - Genomic structure, tissue expression and chromosomal location of the LIM-only
      gene, SLIM1.
PG  - 203-7
AB  - Human SLIM1 is a recently described gene of the LIM-only class encoding four and 
      a half tandemly repeated LIM domains. LIM domains are double zinc finger
      structures which provide an interface for protein/protein interactions and are
      conserved in a variety of nuclear and cytoplasmic factors important in cell fate 
      determination and cellular regulation. Here we report the structural
      organization, expression pattern and chromosomal localization of the human SLIM1 
      gene. SLIM1 was found to contain at least five exons with all four introns
      disrupting the coding region at a similar position relative to the respective
      complete LIM domains. Northern blot analysis confirmed strikingly high expression
      of SLIM1 in skeletal muscle and heart, with much lower expression observed in
      several other tissues including colon, small intestine and prostate. The SLIM1
      gene was assigned to human chromosome Xq26 using fluorescence in situ
      hybridization.
FAU - Greene, W K
AU  - Greene WK
AD  - TVW Telethon Institute for Child Health Research, Division of Childrens'
      Leukaemia and Cancer Research, West Perth, WA 6872, Australia.
      greenew@numbat.murdoc.edu.au
FAU - Baker, E
AU  - Baker E
FAU - Rabbitts, T H
AU  - Rabbitts TH
FAU - Kees, U R
AU  - Kees UR
LA  - eng
SI  - GENBANK/AF110763
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (FHL1 protein, human)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (Muscle Proteins)
SB  - IM
MH  - *Chromosome Mapping
MH  - Exons
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intracellular Signaling Peptides and Proteins
MH  - Introns
MH  - LIM Domain Proteins
MH  - Muscle Proteins/biosynthesis/*chemistry/*genetics
MH  - Muscle, Skeletal/chemistry/metabolism
MH  - Organ Specificity
MH  - X Chromosome/genetics
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - S0378111999001250 [pii]
AID - 10.1016/s0378-1119(99)00125-0 [doi]
PST - ppublish
SO  - Gene. 1999 May 31;232(2):203-7. doi: 10.1016/s0378-1119(99)00125-0.