PMID- 10352228
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20191210
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 232
IP  - 2
DP  - 1999 May 31
TI  - Identification and characterization of a protein containing formin homology
      (FH1/FH2) domains.
PG  - 173-82
AB  - A novel member of the Formin/Diaphanous family of proteins was cloned and
      characterized. A 4kB mRNA is ubiquitously expressed but is found in abundance in 
      the spleen. FHOS (Formin Homologue Overexpressed in Spleen) contains a 3414bp
      open reading frame and encodes for an approximately 128kDa protein. FHOS has
      sequence homology to Diaphanous and Formin proteins within the Formin Homology
      (FH)1 and FH2 domains. FHOS also contains a coiled-coil, a collagen-like domain, 
      two nuclear localization signals, and several potential PKC and PKA
      phosphorylation sites. FHOS-specific antiserum was generated and used to
      determine that FHOS is a predominantly cytoplasmic protein and is expressed in a 
      variety of human cell lines. FHOS was mapped to chromosome 16q22 between
      framework markers WI-5594 and WI-9392.
FAU - Westendorf, J J
AU  - Westendorf JJ
AD  - Vanderbilt University, Department of Biochemistry and Vanderbilt Cancer Center,
      Nashville, TN 37232, USA.
FAU - Mernaugh, R
AU  - Mernaugh R
FAU - Hiebert, S W
AU  - Hiebert SW
LA  - eng
SI  - GENBANK/AF113615
GR  - R01-AG13726/AG/NIA NIH HHS/United States
GR  - R01-CA64140/CA/NCI NIH HHS/United States
GR  - R01-CA77274/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (FHOD1 protein, human)
RN  - 0 (Fetal Proteins)
RN  - 0 (Formins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 16/genetics
MH  - Cloning, Molecular
MH  - Female
MH  - Fetal Proteins/biosynthesis/*chemistry/*isolation & purification
MH  - Formins
MH  - HL-60 Cells
MH  - Humans
MH  - Microfilament Proteins
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/biosynthesis/*chemistry/*isolation & purification
MH  - RNA/analysis
MH  - Sequence Alignment
MH  - *Sequence Homology, Amino Acid
MH  - Spleen/metabolism
MH  - Tumor Cells, Cultured
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - S0378111999001274 [pii]
AID - 10.1016/s0378-1119(99)00127-4 [doi]
PST - ppublish
SO  - Gene. 1999 May 31;232(2):173-82. doi: 10.1016/s0378-1119(99)00127-4.