PMID- 10352227
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 232
IP  - 2
DP  - 1999 May 31
TI  - Structure of human ornithine decarboxylase antizyme 2 gene.
PG  - 165-71
AB  - Ornithine decarboxylase antizyme 1, a negative regulator of polyamine levels,
      acts by destabilizing the first enzyme in the polyamine biosynthetic pathway
      (ODC) and by inhibiting uptake of polyamines. Recently, a second mammalian
      antizyme was discovered. Here, we report the genomic organization and chromosomal
      position of the new human gene, HuAZ2, and make a comparison with its antizyme 1 
      homologue. Fluorescence in-situ hybridization (FISH) localized the sequences from
      a bacterial artificial chromosomal (BAC) clone containing HuAZ2 at band 22 of the
      long arm of chromosome 15. This gene spans at least 15kb and contains five exons.
      No CAAT or TATA sequences could be identified within 800bp upstream of the
      translation initiation codon, but the 5'-flanking region contains several
      putative binding sites for other transcription factors. Transcription initiation 
      of this gene appears to be heterogeneous.
FAU - Zhou, J
AU  - Zhou J
AD  - Department of Human Genetics, University of Utah, Salt Lake City, UT 84112-5330, 
      USA.
FAU - Atkins, J F
AU  - Atkins JF
FAU - Gesteland, R F
AU  - Gesteland RF
LA  - eng
GR  - R01-GM48152/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (5' Untranslated Regions)
RN  - 0 (Ornithine Decarboxylase Inhibitors)
RN  - 0 (Proteins)
RN  - 0 (ornithine decarboxylase antizyme)
SB  - IM
MH  - 5' Untranslated Regions/genetics
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - *Genes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Molecular Sequence Data
MH  - *Ornithine Decarboxylase Inhibitors
MH  - Proteins/*chemistry/*genetics
MH  - Sequence Analysis, DNA
MH  - Transcription, Genetic
EDAT- 1999/06/03 00:00
MHDA- 1999/06/03 00:01
CRDT- 1999/06/03 00:00
PHST- 1999/06/03 00:00 [pubmed]
PHST- 1999/06/03 00:01 [medline]
PHST- 1999/06/03 00:00 [entrez]
AID - S0378111999001286 [pii]
AID - 10.1016/s0378-1119(99)00128-6 [doi]
PST - ppublish
SO  - Gene. 1999 May 31;232(2):165-71. doi: 10.1016/s0378-1119(99)00128-6.