PMID- 10350354
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 64
IP  - 20
DP  - 1999
TI  - A specific loss of C-series gangliosides in pancreas of streptozotocin-induced
      diabetic rats.
PG  - 1803-10
AB  - Gangliosides in pancreas, kidney, and liver tissues from streptozotocin-induced
      diabetic rats were analyzed by methods including thin-layer chromatographic (TLC)
      immunostaining with a specific monoclonal antibody to c-series gangliosides. In
      rats suffering diabetes for one month, the composition of major gangliosides in
      pancreatic tissue was almost identical to control, except for a slight increase
      in the content of GM3. Though c-series gangliosides such as GT3, GT2, GQ1c, and
      CP1c were expressed in normal pancreatic tissue, they were practically lost in
      pancreas of diabetic animals. A specific loss of c-series gangliosides was also
      observed in pancreatic tissue from rats suffering diabetes only for three days.
      While the composition of major gangliosides in the kidney did not change,
      streptozotocin-induced diabetic conditions brought about significant increases in
      contents of practically all major ganglioside species in liver tissue. No change 
      was observed in the amount and composition of c-series gangliosides in both
      tissues. These results strongly suggest that c-series gangliosides are
      specifically localized in pancreatic B cells.
FAU - Saito, M
AU  - Saito M
AD  - Department of Clinical Pharmacology and Therapeutics, University of Shizuoka
      School of Pharmaceutical Sciences, Japan. saitom@ys2.u-shizuoka-ken.ac.jp
FAU - Ito, M
AU  - Ito M
FAU - Sugiyama, K
AU  - Sugiyama K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Blood Glucose)
RN  - 0 (Gangliosides)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Body Weight
MH  - Chromatography, Thin Layer
MH  - Diabetes Mellitus, Experimental/chemically induced/*metabolism
MH  - Disease Models, Animal
MH  - Gangliosides/chemistry/*metabolism
MH  - Kidney/metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Pancreas/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1999/06/01 00:00
MHDA- 1999/06/01 00:01
CRDT- 1999/06/01 00:00
PHST- 1999/06/01 00:00 [pubmed]
PHST- 1999/06/01 00:01 [medline]
PHST- 1999/06/01 00:00 [entrez]
AID - S0024320599001228 [pii]
AID - 10.1016/s0024-3205(99)00122-8 [doi]
PST - ppublish
SO  - Life Sci. 1999;64(20):1803-10. doi: 10.1016/s0024-3205(99)00122-8.