PMID- 10349840
OWN - NLM
STAT- MEDLINE
DCOM- 19990614
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 72
IP  - 6
DP  - 1999 Jun
TI  - Prostate apoptosis response-4 production in synaptic compartments following
      apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial
      dysfunction and neuronal degeneration.
PG  - 2312-22
AB  - Synapses are often located at great distances from the cell body and so must be
      capable of transducing signals into both local and distant responses. Although
      progress has been made in understanding biochemical cascades involved in neuronal
      death during development of the nervous system and in various neurodegenerative
      disorders, it is not known whether such cascades function locally in synaptic
      compartments. Prostate apoptosis response-4 (Par-4) is a leucine zipper and death
      domain-containing protein that plays a role in neuronal apoptosis. We now report 
      that Par-4 levels are rapidly increased in cortical synaptosomes and in dendrites
      of hippocampal neurons in culture and in vivo, following exposure to apoptotic or
      excitotoxic insults. Par-4 expression is regulated at the translational level
      within synaptic compartments. Par-4 antisense treatment suppressed mitochondrial 
      dysfunction and caspase activation in synaptosomes and prevented death of
      cultured hippocampal neurons following exposure to excitotoxic and apoptotic
      insults. Local translational regulation of death-related proteins in synaptic
      compartments may play a role in programmed cell death, adaptive remodeling of
      synapses, and neurodegenerative disorders.
FAU - Duan, W
AU  - Duan W
AD  - Sanders-Brown Research Center on Aging, University of Kentucky, Lexington 40536, 
      USA.
FAU - Rangnekar, V M
AU  - Rangnekar VM
FAU - Mattson, M P
AU  - Mattson MP
LA  - eng
GR  - AG05119/AG/NIA NIH HHS/United States
GR  - AG14554/AG/NIA NIH HHS/United States
GR  - NS35253/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Oligodeoxyribonucleotides, Antisense)
RN  - 0 (prostate apoptosis response-4 protein)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - EC 3.4.22.- (Caspases)
RN  - H88EPA0A3N (Staurosporine)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Apoptosis Regulatory Proteins
MH  - Brain/*physiology
MH  - Carrier Proteins/biosynthesis/*genetics
MH  - Caspases/*metabolism
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Dendrites/drug effects/physiology
MH  - Female
MH  - Gene Expression Regulation/physiology
MH  - Glutamic Acid/pharmacology
MH  - Hippocampus/physiology
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Kainic Acid/toxicity
MH  - Male
MH  - Mitochondria/drug effects/*metabolism
MH  - Nerve Degeneration/*physiopathology
MH  - Neurites/drug effects/physiology
MH  - Neurons/cytology/drug effects/*physiology
MH  - Oligodeoxyribonucleotides, Antisense/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction
MH  - Staurosporine/pharmacology
MH  - Synapses/drug effects/*physiology
MH  - Synaptosomes/physiology
EDAT- 1999/06/01 00:00
MHDA- 1999/06/01 00:01
CRDT- 1999/06/01 00:00
PHST- 1999/06/01 00:00 [pubmed]
PHST- 1999/06/01 00:01 [medline]
PHST- 1999/06/01 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.0722312.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 Jun;72(6):2312-22. doi: 10.1046/j.1471-4159.1999.0722312.x.