PMID- 10349617
OWN - NLM
STAT- MEDLINE
DCOM- 19990720
LR  - 20191210
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 79
IP  - 1-2
DP  - 1998 Dec
TI  - A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is
      expressed during early embryogenesis.
PG  - 17-27
AB  - The transcription factor FAST-1 has recently been shown to play a key role in the
      specification of mesoderm by TGF beta superfamily signals in the early Xenopus
      embryo. We have cloned Fast1, a mouse homologue of Xenopus FAST-1, and
      characterized its expression during embryogenesis and function in activin/TGF
      beta signal transduction. In vitro, Fast1 associates with Smads in response to an
      activin/TGF beta signal to form a complex that recognizes the Xenopus activin
      responsive element (ARE) targeted by Xenopus FAST-1. In intact cells,
      introduction of Fast1 confers activin/TGF beta regulation of an ARE-luciferase
      reporter. In embryos, Fast1 is expressed predominantly throughout the epiblast
      before gastrulation and declines as development progresses. We propose that mouse
      Fast1, like Xenopus FAST-1, mediates TGF beta superfamily signals specifying
      developmental fate during early embryogenesis.
FAU - Weisberg, E
AU  - Weisberg E
AD  - Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
FAU - Winnier, G E
AU  - Winnier GE
FAU - Chen, X
AU  - Chen X
FAU - Farnsworth, C L
AU  - Farnsworth CL
FAU - Hogan, B L
AU  - Hogan BL
FAU - Whitman, M
AU  - Whitman M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (FOXH1 protein, Xenopus)
RN  - 0 (FOXH1 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxh1 protein, mouse)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (SMAD2 protein, human)
RN  - 0 (SMAD3 protein, human)
RN  - 0 (SMAD4 protein, human)
RN  - 0 (Smad Proteins)
RN  - 0 (Smad2 Protein)
RN  - 0 (Smad2 protein, Xenopus)
RN  - 0 (Smad2 protein, mouse)
RN  - 0 (Smad3 Protein)
RN  - 0 (Smad3 protein, mouse)
RN  - 0 (Smad4 Protein)
RN  - 0 (Smad4 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Xenopus Proteins)
RN  - 0 (madh3 protein, Xenopus)
RN  - 0 (smad4.1 protein, Xenopus)
RN  - 0 (smad4.2 protein, Xenopus)
SB  - IM
MH  - Animals
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Forkhead Transcription Factors
MH  - Gastrula/physiology
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - Mice/*embryology
MH  - Nerve Growth Factors
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Smad Proteins
MH  - Smad2 Protein
MH  - Smad3 Protein
MH  - Smad4 Protein
MH  - Trans-Activators/genetics/metabolism
MH  - Transcription Factors/*genetics/metabolism
MH  - Transcription, Genetic
MH  - Transforming Growth Factor beta/*metabolism
MH  - Xenopus
MH  - *Xenopus Proteins
EDAT- 1999/06/01 00:00
MHDA- 1999/06/01 00:01
CRDT- 1999/06/01 00:00
PHST- 1999/06/01 00:00 [pubmed]
PHST- 1999/06/01 00:01 [medline]
PHST- 1999/06/01 00:00 [entrez]
AID - S0925-4773(98)00160-9 [pii]
AID - 10.1016/s0925-4773(98)00160-9 [doi]
PST - ppublish
SO  - Mech Dev. 1998 Dec;79(1-2):17-27. doi: 10.1016/s0925-4773(98)00160-9.